{"paper_id":"ea21ce76-98ab-490c-8f99-33db2380d429","body_text":"International Journal of Clinical and Experimental Medicine Research, 2020, 4(4), 242-247 \nhttp://www.hillpublisher.com/journals/ijcemr/ \nISSN Online:  2575-7970 \nISSN Print: 2575- 7989 \n \nDOI: 10.26855/ijcemr.2020.10.020 242 International Journal of Clinical and Experimental Medicine Research \n \nDiscussion on Synchronization of Liver, Spleen and \nKidney in Treating Endometriosis from Blood \nStasis  \nYuanyuan Liu, Xinchun Xiao* \nShaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712000, China. \n \n \n \nHow to cite this paper: Yuanyuan Liu, \nXinchun Xiao. (2020) Discussion on \nSynchronization of Liver, Spleen and \nKidney in Treating Endometriosis from \nBlood Stasitance. International Journal of  \nClinical and Experimental Medicine \nResearch, 4(4), 242-247. \nDOI: 10.26855/ijcemr.2020.10.020 \n \nReceived: October 13, 2020 \nAccepted: November 6, 2020 \nPublished: November 16, 2020 \n \n*Corresponding author:  Xinchun \nXiao, Shaanxi University of Traditional \nChinese Medicine, Xianyang, Shaanxi, \n712000, China. \nEmail: xxchsd2003@163.com \n \n  Abstract \nEndometriosis has a high incidence in women of childbearing age in recent \nyears, and it has received attention because it greatly affects women’s physical \nand mental health. In recent years, Chinese medicine practitioners have clearly \nconfirmed that “stasis” is the main etiology and pathogenesis. However, in the \ntheory of Chinese medicine, the formation of blood stasis is closely related to \nthe main pathogenic factors of liver, spleen and kidney three organ dysfunc-\ntion. Maintaining vitality, reserving the essence of the kidney, reproducing the \nmain body, and coordinating the liver, spleen, and kidney to harmonize blood, \nblood, and blood, alleviate and reverse the series of symptoms brought by e n-\ndometriosis. In terms of the relationship between the formation of endometr i-\nosis and irregular menstruation, dysmenorrhea, dysmenorrhea, infertility and \nother symptoms, it is planned to use the view of liver and spleen and kidney \nhomology in Chinese medic ine to explore the relationship between stasis and \nthe incidence of endometriosis To further study the pathogenesis and preve n-\ntive treatment of endometriosis provides a theoretical basis. \n \nKeywords \nEndometriosis, stasis, synchronization of l iver, spleen and kidney , treatment \nbased on syndrome differentiation \n \nEndometriosis (endometriosis) is one of the most common diseases in gynecology. It refers to the appearance, \ngrowth, infiltration and repeated bleeding of endometrial tissue (glands and stroma) in the endometrium and other \nparts of the uterus, and then causes pain, infertility, nodules or masses and other symptoms, accounting for about \n40% of the causes of infertility, and 90% of the patients have pelvic pain [1]. About 176 million women aged \n15-49 are currently affected by endometriosis worldwide [2]. \nModern medical research has shown that endometriosis is an estrogen-dependent disease [3]. Its treatment is \ncomplex, and currently approved hormone therapy for endometriosis can effectively control symptoms, but may \nhave clinically relevant side effects, limiting its long-term use [4]. In 2019, the Chinese Society of Integrated \nChinese and Western Medicine Department of Obstetrics and Gynecology issued the latest “Endometriosis Inte-\ngrated Chinese and Western Medicine diagnosis and treatment guidelines” will belong to the traditional Chinese \nmedicine “blood stasis syndrome” treatment category [5]. Treatment with “removing blood stasis method” can \neffectively improve the symptoms of discomfort, relieve pain, improve pregnancy rate, and no obvious side effects. \nTherefore, from the point of view of “blood stasis”, combined with clinical and internal heterosis, the etiology and \npathological basis of western medicine, further explore the liver, spleen and kidney same way to treat endometri-\n\nYuanyuan Liu, Xinchun Xiao \n \n \nDOI: 10.26855/ijcemr.2020.10.020 243 International Journal of Clinical and Experimental Medicine Research \n \nosis pathological mechanism and treatment. \n1. “Stasis” is the basic cause and pathogenesis of internal heterosis \nTang Rongchuan “Blood Syndrome Theory” said: “Since it is blood from the meridian, although clear blood, \nblood, but also blood stasis”. Blood stasis syndrome, as an important syndrome in TCM syndrome differentiation, \nrefers to the performance caused by the stagnation of blood flow in the pulse tube or the stopping of blood accu-\nmulation outside the blood overflow pulse [6]. \nEndometriosis has no special name in traditional Chinese medicine. At present, a large number of doctors have \nobserved that its clinical manifestations and signs are very similar to those of dysmenorrhea, irregular menstrua-\ntion, infertility and tumor in traditional Chinese medicine. Therefore, referring to ancient books, we can see that \nancient doctors often blame the etiology and pathogenesis of similar symptoms of endometriosis as “stasis”. \n“Blood stasis” causes the uterus to flush, qi and blood is not smooth. Then there is no glory, impassable, causing \ndysmenorrhea; blood stasis stop, Chong Ren damage, cannot become pregnant, so long marriage infertility; blood \nstasis, collateral obstruction, gradually become a tumor. \nModern studies have also confirmed that patients with endometriosis have slow microcirculation stasis, high \nblood coagulation state, poor fluidity, strong, sticky, coagulation, aggregation and other characteristics, but after \nthe treatment of blood circulation and blood stasis, microcirculation and blood flow have improved [7]. Therefore, \n“blood stasis” runs through the development of endometriosis, and “blood stasis” is the most basic pathological \nbasis of endometriosis. \n2. Relationship between blood stasis caused by liver disorders and endometriosis \n2.1 The liver hides blood and drains \n“Blood is the master of the liver, and evil blood must be attributed to the liver”, Li said in the Medical Invention, \n“Blood Syndrome Theory” said: “The liver is the main blood... Then the liver belongs to wood, wood qi rush and \nstrip reach, do not suppress depression, then the blood vessels are unobstructed”, indicating that liver drainage is \nvery important to the operation of blood. If the liver is lost, it will lead to stagnation of liver qi, stagnation of heat \nand fire, dampness and heat of liver meridian, hyperactivity of liver yang, internal movement of liver wind and so \non, resulting in many gynecological diseases [8]. Drainage function is normal, the air machine will be smooth, and \nthen blood circulation. On the contrary, if the blood flow disorder, will produce blood stasis. Drainage function is \nnormal, the air machine will be smooth, and then blood circulation. On the contrary, if the blood flow disorder, \nwill produce blood stasis [9] Notes. The liver participates in fibrin synthesis and dissolution, and ensures the sta-\nbility of the coagulation system by removing coagulation factors, fibrinolytic activators, and free heparin. In order \nto maintain the normal operation of the blood, not to produce blood stasis, internal abnormalities. \n2.2 The liver is connected with Chong and Ren \n“Lingshu Jing” said: “Chong, Ren are all from the cell, on the back, for the sea of meridians”. “Chong Xue \nHai”, “Let the main child”, the physiological activities of women such as menstruation, belt, fetus, birth and lacta-\ntion are all related to rush. If qi and blood deficiency, will lead to blood flow of the degree of unobstructed limited, \nand then blood stasis block in the Chong, Ren Ermai, slowly will lead to abdominal pain, amenorrhea and other \nsymptoms [10]. The Fu Jueyin Liver Meridian and Ren Mai meet “Qu Gu” [11]. There are many similarities be-\ntween the liver meridian and Chong Ren two veins. The woman takes the liver as the congenital, the liver blood is \nfull, the two functions of storing blood and dredging each other cooperate and coordinate, the blood sea will over-\nflow on time, rush and let go, and the uterus will leak for a period to maintain the normal function of the woman. \nLiver loss and catharsis affect Chong Ren, stagnation of liver qi and blood disorder, menstrual blood is not smooth, \nimpassable pain, dysmenorrhea; Qi accumulation blood coagulation, and countercurrent meridian blood mutual \ncementation, accumulation of abdominal mass, is a tumor; blood stasis, uterine diarrhea dysfunction, so that the \ntwo spermatozoa cannot fight, resulting in infertility. \n3. Relationship between Spleen Disorder and Stasis and Endometriosis \n3.1 Spleen blood, main transport water dampness \nThe synopsis of the Golden Chamber says: “The blood of the five viscera and the six entrails depends on the \ncontrol of temper”. If the function of the spleen is normal, the blood circulation does not overflow the veins and \n\nYuanyuan Liu, Xinchun Xiao \n \n \nDOI: 10.26855/ijcemr.2020.10.020 244 International Journal of Clinical and Experimental Medicine Research \n \ncause blood stasis. “Medical Mind Understanding” says: “The spleen is the source of sputum”. A brief summary \nof the spleen in the water metabolism plays an important role—the transport of water valley fine, scattered its es-\nsence to supply the viscera, and prevent the accumulation of excess water in the body. The deficiency of temper is \nnot good, the clear is difficult to rise, the turbid is difficult to fall, the body fluid is abnormal, the water dampness \nstops inside, and the dampness gathers into phlegm. The solid is because the patient usually eats greasy, conti-\nnuously injures its spleen function, thus causes the patient to endogenetic phlegm dampness, accumulates the \nstagnation to stay in the cell palace, causes the patient to have the blood circulation disorder, displays both the qi \nstagnation and the blood stasis. The symptoms make the blood flow of the patient blocked [12]. Also because of \n“wet sex trend, easy to attack genitalia”, endometriosis is located in the lower coke, blood stasis remains, blood \nstasis and dampness mutual knot, accumulated for a long time heat, dampness and heat stasis knot, formed the \ncharacteristics of internal heterosis cementation difficult to solve, lingering difficult to heal. \n3.2 The spleen is in the middle of the spleen \nZhu Danxi said: “The spleen has the virtue of Kun Jing, and has the luck of the world, so it can make the heart \nand lung Yang drop, kidney and liver Yin rise, and become the heaven and earth of the Thai [13]. It shows that the \nspleen is located in the middle part, and its normal function can make the middle Jiao Qi prosperous, clear Qi is \nrising, the upper heart and lung are transported, the liver and kidney are issued, and the four sides are irrigated \noutside. Modern medicine [14-17] Notes, spleen is the largest immune organ in human periphery, which is closely \nrelated to cellular immunity, humoral immunity and endocrine metabolism. This function is very similar to the \nfunction of spleen in traditional Chinese medicine. Basis of the normal operation of the body’s blood—the mutual \nbalance of the anticoagulant and coagulation systems, if this balance is destroyed, it may lead to hemorrhagic dis-\nease or thrombus in patients, that is, “blood stasis”. The endocrine disorders and metabolic disorders in patients \nwith endometriosis will enhance the platelet activity, and then increase the synthesis and secretion of plasma P- \nselectin (Ps), Ps through the continuous combination with platelets and endothelial cells, so that the coagulation \nsystem of the patient’s body can be obtained. To activate, form “stasis” [18-19]. But the experiment [20-23] Con-\nfirmation, women’s endocrine disorders can lead to a series of symptoms of endometriosis. It shows that spleen \ndysfunction will affect the operation of qi and blood throughout the body, leading to the formation of blood stasis \nsyndrome. And then lead to irregular menstruation, infertility, tumor and other symptoms. \n4. Relationship between blood stasis caused by renal disorders and endometriosis \n4.1 Kidney contains essence, main reproduction \nThe woman is seven years old, the kidney is full, and the teeth are longer. Two and seven days to, Ren Mai \nTong, too Chong pulse Sheng, the month to the present, so there are children… Seven Ren pulse deficiency. Too \npulse decline less, day Kui exhausted, tunnel impassable, so bad shape and no son also. “Shenqi Sheng” means \nthat the kidney qi is sufficient, and the two conditions are the growth and development of women, menstruation, \nbirth of children, the prerequisite, basic elements, indicating that kidney and female physiological function is \nclosely related. Kidney contains essence, kidney is the key zang-fu organs of reproduction and development, the \nessence of the five viscera are attributed to the kidney, essence can blood, blood can produce essence, “essence \nand blood homology”, kidney yang weakness, then Deficiency of vital qi, lack of warm body, decline of nourish-\ning function, easy to cause cold and dampness, internal obstruction of blood stasis, impassable meridians, discord \nof qi and blood, and then infertility, dysmenorrhea, tumor and a series of diseases. \n4.2 Kidney system Chong Ren, main birth \nSu asked the theory of strange disease, said: “more than the kidney”. The kidney qi is sufficient, as the place of \nmenstruation and gestation, the palace can get sufficient nourishing and warm, can the qi and blood fill, play its \nutility. Chong all originated in the cell, by the pulse, through the kidney qi. Therefore, the rise and fall of kidney qi, \ndetermine the profit and loss, the palace of Tibetan diarrhea. The kidney essence is sufficient, the pulse can nou-\nrish, the blood sea is full, the menstruation can be fixed and down, and the blood is unobstructed. Kid-\nney-TianGui-ChongRen-Cypterian axis interlocking, maintaining the uterine diarrhea, storage overflow. If the \nkidney is deficient in essence, then Chong, Ren, lost the pulse nourishing, the palace diarrhea dereliction of dut y, \nslow blood, easy to become stasis, Stasis makes blood do not return to menstruation, there will be irregular men-\nstruation, dysmenorrhea, so that eggs cannot be combined and infertility. Such as body and kidney deficiency, \nYang Qi inhibition, Yin cold Sheng, Chong Renqi lost in warm, blood for cold coagulation, blood stasis and stag-\n\nYuanyuan Liu, Xinchun Xiao \n \n \nDOI: 10.26855/ijcemr.2020.10.020 245 International Journal of Clinical and Experimental Medicine Research \n \nnation for this disease. Blood stasis for Yin evil, blood stasis removal, cell palace unobstructed, if the blood stasis \nfor a long time, Yin essence cannot be transformed, Yang Qi cannot be declared, but also aggravated kidney defi-\nciency. It can be seen that kidney deficiency and blood stasis are causes and consequences, leading to the occur-\nrence of internal disorders, menstrual disorders, dysmenorrhea, and even infertility and other syndromes. \n5. Relationship between liver, spleen and kidney \nEndometriosis is characterized by irregular menstruation, dysmenorrhea, infertility and dysuria. Traditional \nmedicine emphasizes the “holistic view”, and man himself is an organic whole. In this whole, meridians, viscera \nand material functions all cooperate, restrict and influence each other. The pathogenesis of endometriosis is close-\nly related to liver, spleen and kidney. If the liver loses and drains and causes the Qi machine to adjust the function \nto be abnormal, the liver depression injures the spleen for a long time, the spleen and stomach turns out to be an-\ngry and the blood fluid lacks the source, but cannot nourish the whole body, causes the acquired loss of nourish-\nment; the spleen damage is kidney injury, plus the congenital endowment insufficiency, therefore the physique is \nweak. Long kidney does not hide essence, essence and blood cannot be transformed, cannot be filled with the pa-\nlace, and gynecological diseases. In addition, the kidney is the birth of the essence of the main viscera and hide, \nspleen and stomach for the day after tomorrow, the essence of the day after tomorrow water valley scattered, con-\ngenital warm to stimulate the day after tomorrow, acquired supplementary cultivation of congenital, congenital \nand acquired mutual health, mutual promotion, functional coordination. Spleen and liver together for the gas en-\ngine hub, the three together regulate the whole body qi and blood operation. Liver, spleen and kidney function can \nactivate blood circulation, nourish essence and store sharp to enhance autoimmune and resist external evil. If their \nown qi and blood deficiency, the function of the viscera gradually decline, it is easy to lead to the loss of the pulse, \nand the stagnation of the meridian qi, qi and blood unobstructed, resulting in Chong, Ren, du cell pulse dysfunc-\ntion, resulting in some miscellaneous diseases [24]. \n6. Syndrome Differentiation and Treatment of Internal Disorders Based on “Blood Stasis” and \nConsistency of Live r, spleen and Kidney \n6.1 Syndrome Differentiation and Treatment of Internal Disorders Based on “Blood Stasis” and Con-\nsistency of Live r, spleen and Kidney \nLiver catharsis, Heizuda, evil depression, has the function of regulating emotion, and people in modern society \nbear all kinds of pressure, the influence of emotion change on liver is very great, heparin depression, or anger in-\njury liver, wood loss, Qi machine is not smooth, blood lag, blood stasis internal obstruction of the uterus, Chong \nRen, then developed endometriosis. Qi stagnation and blood stasis syndrome has become the most common syn-\ndrome type in modern clinical endometriosis. Qu Qiyun [25] Four inverse San Yua n recipe (Bupleurum 15g,) for \nrelieving depression and soothing liver and regulating qi Radix Paeoniae Alba 20 g, Fructus Aurantii 15 g, Radix \nGlycyrrhizae 15 g) was used to treat dysmenorrhea caused by endometriosis. Wang Hong and other [26] believe \nthat qi stagnation and blood stasis in endometriosis is the most common type, Decoction of Removing Blood Sta-\nsis from Diaphragm (Angelica sinensis 10 g, with the function of soothing liver and regulating qi to remove blood \nstasis Chuanxiong 5 g, 10 g, peony 10 g, of red peony Peach kernel 10 g, 10 g, safflower Pentol 10 g, Annex 10 g, \n10 g, of black medicine Fructus Aurantii 10 g, 10 g, Yanhusuo Glycyrrhiza uralensis 15 g) was used in clinic and \nthe control group was set up for observation. The results show that the decoction can effectively reduce the serum \nCA125, turn EmAB Yin and relieve the pain symptoms of patients with internal heterosis. Hou Jianling [27] The \nclinical observation found that the drugs of promoting blood circulation and removing blood stasis and regulating \nqi and relieving pain in Danshen Huoxue decoction are helpful to alleviate the adhesion and reduce the mass of \nthe patients, thus alleviating the pain of the patients and achieving the purpose of relieving the symptoms quickly. \n6.2 Invigorating spleen and removing blood stasis \n“The origin of the disease” cloud: “all phlegm, this by blood congestion, drinking water accumulation and not \ndissipate, so phlegm also”. This article shows that phlegm turbid due to blood congestion, drinking water accu-\nmulation, blood stasis for a long time, stasis Qi stagnation, Sanjiao gasification is not smooth, then wet into \nphlegm. Whether it is dampness and heat stasis knot or phlegm and blood stasis caused by irregular menstruation, \ndysmenorrhea or infertility, in the final analysis, but the usual food paste thick taste, or liver Wangke spleen, \nspleen deficiency transport loss, phlegm turbid endogenetic, and blood from the meridian, phlegm and blood stasis \nmutual knot, rushed or not solid. Fu Shuxiu [28] etc. Composing spleen and removing blood stasis formula g, \n\nYuanyuan Liu, Xinchun Xiao \n \n \nDOI: 10.26855/ijcemr.2020.10.020 246 International Journal of Clinical and Experimental Medicine Research \n \nCodonopsis 15 Cloud Poria cocos 15g, 10g, of Atractylodes macrocephala Astragalus g,15 Peach kernel 10 g, 10 g, \npastry 15 g, of red peony Guizhi 6g, 30g, of soap Curcuma g.10 Anal pain obvious plus 6 g, of wood incense \nBlack medicine 6 g; 6 g, of Evodia rutaecarpa plus Gun 6 g; Add 6 g, to the yellow 10 g. Scutellaria baicalensis \nClinical observation of 46 patients with endometriosis. It was found that tonifying spleen can effectively treat a \nseries of symptoms caused by endometriosis. Yue Xiaoqiang [29] etc. add and subtract Yiqi decoction and Xiaox-\niao Powder (Radix Glycyrrhizae 6 g, Chen Pei 12 g, Use cases 15 g, Bupleurum 9 g, Rhizoma cimicifugae 6 g, \nWhite peony 18 g, Salvia miltiorrhiza 18 g, Chicken blood vine 30 g, Pollen Typhae 9 g, Wulingzhi 9 g, Biejia 12 \ng, Chicken nugget 18 g, Codonopsis pilosula 30 g, Roasted Astragalus 30 g, Atractylodes macrocephala 30 g) to \ninvigorate qi and spleen, Promoting blood circulation and removing blood stasis in the treatment of symptoms \nbrought by endometriosis has a better effect. \n6.3 Treatment of Endometriosis by Invigorating Kidney and Removing Blood stasis \nKidney deficiency is a disease, whether kidney yin deficiency or kidney yang deficiency will have pathological \nchanges caused by deficiency. Choroid stasis, blood flow is not smooth, it hinders the kidney yin, kidney yang \nmetaplasia. Wang Wenjuan etc. [30] Using the method of tonifying kidney and removing blood stasis to divide the \npatients with endometriosis according to the stage before and after ovulation, Preparation before ovulation (Reh-\nmannia glutinosa 20 g, Cuscuta 20 g, Angelica sinensis 15 g, Salvia miltiorrhiza 15 g, Wulingzhi 15 g, Radix \nPaeoniae Alba 15 g, Zedoary 12 g, chicken blood rattan 12 g, fragrant 12 g, Sichuan Achyranthes bidentata 12 g; \nPoria cocos 10 g, Yanhusuo 10 g, Guizhi 10 g) activating blood stasis, tonifying kidney and nourishing blood. It \ncan promote the transformation of yin and yang in the kidney 25 g, after ovulation Cuscuta chinensis 20 g, \nChicken blood vine 15 g, Epimedium 15 g, Ai Ye 15 g, Yanhusuo 15 g, Guizhi 15 fried white Paeonia lactiflora 15 \ng, Glycyrrhiza uralensis 10 g) with regulating menstruation and relieving pain and tonifying kidney and warming \nmeridian as the main treatment principle, the clinical effect is remarkable and effective. Modern pharmacology \nhas confirmed that tonifying the kidney and removing blood stasis can effectively regulate the endocrine of pa-\ntients and increase the immune function, which has a better effect on the symptoms caused by endometriosis. Han \nLiyan etc. [31] To remove turbidity, detoxify kidney, remove blood stasis, draw up the prescription of tonifying \nkidney and removing Rehmannia glutinosa 20 g, Dodder 20 g, Chinses angelica 15 g, Salvia miltiorrhiza Bge 15 g, \nWulingzhi 15 g, Red Peony15 g, Rhizoma Curcumae 12 g, Caulis Spatholobus 12 g, Rhizoma Cyperi 12 g, Si-\nchuan Ach knee 12 g; Poria cocos 10 g, Yancho 10 g, Guizhi 10 g was used in endometriosis model rats. At the \nmolecular level, it is verified that the prescription of removing turbid and detoxifying kidney and removing blood \nstasis may promote blood operation, to improve the condition of ischemia and hypoxia, enhancing HIF-1α expres-\nsion, to treat the uterus the efficacy of the aim of endometriosis. \n7. Conclusion \nFor endometriosis, it is mainly due to the imbalance of liver, spleen and kidney, stagnation of qi and blood, and \nunobstructed meridian qi, which leads to local lesions. It is found that the basic methods of treating endometriosis, \nwhether based on clinical practice or laboratory exploration, cannot be separated from the treatment of endome-\ntriosis. \nReferences \n[1] Kodaman, P. H. (2015). Current strategies for endometriosis man -agement [J]. Obstet Gynecol Clin North Am , 2015, 42(1): \n87-101. \n[2] Rocha, A. L., Reis, F. M., Taylor, R. N. (2013). Angiogenesis and endometriosis [J]. Obstet Gynecol Int, 2013: 859619. \n[3] Kennedy, S., Bergqvist, A., Chapron, C., et al. (2005). ESHRE guide-line for the diagnosis and treatment of endometriosis  [J]. \nHum Reproduction, 2005, 20(10): 2698-2704. \n[4] Safety of Dienogest and Other Hormonal Treatments for Endometriosis in Real -World Clinical Practice (VIPOS): A Large \nNoninterventional Study. \n[5] Yu Chaoqin, Duan Hua, Xu Hong, et al. (2019). Guidelines for the diagnosis and treatment of endometriosis  [J]. Chinese Jour-\nnal of Integrated Chinese and Western Medicine, 2019(10): 1169-1176. \n[6] Ji Shaoliang, Cheng Zhaozhi. (2009). TCM Diagnostics [M]. Beijing: People’s Health Publishing House, 2009: 126. \n[7] Liu Jinxing, Mao Furong, Zhang Yingchun. (1994). Clinical Study on Treating Endometriosis with Removing Blood Stasis and \nEliminating Phlegm and Soft Jian Powder  [J]. Chinese Journal of Integrated Chinese and Western Medicine, 1994, 14(6):  \n337-339. \n\nYuanyuan Liu, Xinchun Xiao \n \n \nDOI: 10.26855/ijcemr.2020.10.020 247 International Journal of Clinical and Experimental Medicine Research \n \n[8] Yang Xianhai, Yuan Fahui, Chai Jinhua, et al. (2013). Li Zhiyuan’s Academic Thought on the Treatment of Gynecology with \nLiver [J]. Modern Distance Education in Chinese Traditional Chinese Medicine, 2013, 011(003): 96-98. \n[9] Fu Zhengwen. (2017). Changes of blood clotting function index in patients with hepatitis B, liver cirrhosis and liver failure [J]. \nThrombosis and Hemostasis, 2017, 23(4): 609-611. \n[10] Shen Chunhui. (2014). Efficacy of laparoscopic combined repair of diverticulum of uterine incision after cesarean section in 48 \ncases% Effect Observation on Hysteroscopy Combined with Laparoscopy in Repairing 48 Patients with Uterine Scar Defect \nafter Cesarean Section [J]. Clinical Medical Engineering, 2014, 021(012): 1573-1574. \n[11] Wang Weifan. (2005). The Relationship between Liver and Reproduction [J]. Henan Traditional Chinese Medicine,  2005, \n25(11): 9-11. \n[12] Liu Shuhui, Yao Meiyu. (2010). “Three-step Method” for Treating Irregular Menstruation of Kidney Deficiency Type  [J]. Jilin \nTraditional Chinese Medicine, 2010, 30(1): 26-27. \n[13] Tian Sisheng. (2006). Zhu Danxi Medicine [M]. Beijing: China Traditional Chinese Medicine Press, 2006: 20. \n[14] Yousefi Ghale-Salimi M., Eidi M., Ghaemi N., et al. (2018). Inhibitory effects of taraxasterol and aqueous extract of Tara x-\nacum officinale on calci-um oxalate crystallization: in vitro study [J]. Ren Fail, 2018, 40(1): 298-305. \n[15] Ben Khalifa B ., Naouar S., Gazzah W., et al. (2016). Predictive factors of extra-corporeal shock wave lithotripsy success for \nurinary stones [J]. Tunis Med, 2016, 94(5): 397-400. \n[16] Peng Wanda. (2019). Effects of Astragalus Polysaccharide on Insulin Resistance and Nrf2 -ARE Pathway in Gestational D i-\nabetic Rats [J]. Chinese Journal of Physicians, 2019, 21(10): 1507-1512, 1516. \n[17] Wang Sihai, Lin Yixuan, Fang Chaohui, et al. (2020). Clinical study of endocrine and metabolic diseases treated with spleen [J]. \nChinese Journal of Clinical Health, 2020, 23(1): 136-140. \n[18] Xu Jian. (2010). On Kidney Deficiency and Menstrual Disease [J]. Chinese and Foreign Medical Research, 2010, 8(26): 172. \n[19] Close the edge. Effect of Bushen Fu spleen Yangxue Decoction on Treating Menstrual Disease of Kidney Deficiency Type and \nEffect on Reproductive Hormone Level and Coagulation Status of Patients [J]. Chinese Medical Science, 2017(14). \n[20] Zhong Xuan. (2017). Observation on serum endocrine hormone levels and autoimmunity antibodies in patients with endom e-\ntriosis and infertility [J]. Shenzhen Integrated Chinese and Western Medicine Journal, 2017, 27(8): 12-13. \n[21] Qin Qingshuang, Gao Meihua. (2016). Correlation between endometriosis and immune infertility [J].  Journal of Shandong \nMedical College, 2016, 38(1): 59-61. \n[22] Xu Jing, Xia Qinchun. (2015). Clinical study on endocrine of women with endometriosis a nd infertility [J]. Health nutrition in \nChina, 2015, 25(15): 49. \n[23] Chen Yuanyuan, Lu Zhanbin. (2016). Effects of letrozole on endocrine hormones in endometriosis [J].  Chinese Science, 2016, \n25(12): 65-67. \n[24] Huang Wenjin, Yao Minglong, Ye Yunjin, et al. (2015). Application of Relevance Rules in Diagnosis of TCM Gynecology [J]. \nHunan Journal of Traditional Chinese Medicine, 2015, (08): 148-149. \n[25] Qu Qiyun. (2008). Treatment of endometriosis with soothing liver and regulating qi  [J]. Henan Traditional Chinese Medicine, \n2008, 28: 68-69. \n[26] Wang Hong, Li Yuli, Sun Xiaoyu, et al. (2018). Diaphragm Zhuyu Decoction for Treatment of Endometriosis of Qi stagnation \nand Blood Stasis [J]. Journal of Chinese Medicine, 2018, 33(10): 188-192. \n[27] Hou Jianling. (2008). Salvia miltiorrhiza Huoxue decoction for the treatment of endometriosis in 86 cases. Bright Chinese \nMedicine, 2008, 23(10): 1539. \n[28] Fu Shuxiu, Lu Zhen, Gao Tianyu. (2 007). Treatment of 46 Cases of Endometriosis with Buqi Quyu Prescription [J]. Chinese \nMedicine Clinical Journal, 2007, 19(3): 230-230. \n[29] Yue Xiaoqiang . (2001). Historiography. Discussion on treatment of endometriosis with spleen [J]. Chinese Medicine, 2001, \n12(3): 238-238. \n[30] Wang Wenjuan, Yang Yanhong, Lu Zonglin. (2 018). Effect of tonifying kidney and removing blood stasis in treating endome-\ntriosis infertility [J]. Chinese Folk Medicine Journal, 2018, 27(8): 83-84. \n[31] Han Liyan, Bian Wenhui, Yang Bin, et al. (2 012). Effect of Huazujiedu Bushen Quyu Prescription on FIH -1α of Experimental \nEndometriosis Rats [J]. Jiangsu Traditional Chinese Medicine, 2012(09): 78-79.","source_license":"CC0","license_restricted":false}