{"paper_id":"e9f38d46-3a80-45f7-8f39-b796bcb3ea61","body_text":"Ovarian carcinoma is a heterogeneous disease with a 5-year survival rate below 50%. 1  Primary prevention of the most common histotype of ovarian carcinoma (high-grade serous carcinoma [HGSC], 70% of ovarian carcinomas) is possible using opportunistic bilateral salpingectomy (OBS; the removal of the fallopian tubes during another pelvic surgery while conserving the ovaries). Significant data show that OBS is safe, 2  it does not appear to reduce the age of onset of menopause, 3  and it is cost-effective. 4  Herein, this evidence base is expanded by (1) estimating the risk reduction for serous ovarian cancer afforded by OBS using population-based data; and (2) examining whether the histotype distribution of ovarian carcinomas in people without fallopian tubes significantly differs from the historical histotype distribution.\n\nFor the first aim, we conducted a population-based retrospective cohort study including all people who underwent a hysterectomy or tubal permanent contraception in British Columbia between 2008 and 2020 (eTable 1 and eTable 2 in  Supplement 1 ), with approval from the University of British Columbia’s clinical research ethics board and a waiver of consent due to use of deidentified data. We followed Strengthening the Reporting of Observational Studies in Epidemiology ( STROBE ) reporting guidelines. Risk reduction for serous carcinomas from the population-based data was estimated using Cox proportional hazards models comparing individuals in the OBS group with individuals in the comparison surgery group (hysterectomy alone or tubal ligation). Low- and high-grade serous carcinomas were combined as our data did not specify histotype among serous carcinomas, but HGSC represent 95% of these carcinomas. We repeated the analysis with breast cancer as the outcome to examine the likelihood of selection bias on important unmeasurable differences between the groups (see eMethods in  Supplement 1 ).\nFor the second aim, we asked international pathologists to enter anonymized data into a RedCap database for any ovarian carcinomas occurring in a patient without fallopian tubes (eTable 2 in  Supplement 1 ). The histotype distribution of these cancers was compared with a historical histotype distribution using Fisher exact test. 5  All  P  values were 2-sided, and statistical significance was defined as  P  < .05 for all analyses, which were performed in SAS version 9.4 (SAS Institute) and Stata version 19 (StataCorp) from April 2025 to October 2025.\n\nIn aim 1, there were 85 823 patients who had surgical procedures of interest, 40 527 who underwent OBS (median [IQR] follow-up, 4.72 [2.23-7.09] years), and 45 296 who underwent a comparator surgery (median [IQR] follow-up, 8.45 [6.07-11.51] years). Compared with those who underwent OBS, individuals in the comparison group were older at the time of surgery (mean [SD] age, 42.4 [12.6] vs 40.7 [8.1] years) and had less use of oral contraceptive pills (21 665 individuals [50.0%] vs 23 876 [60.7%]; mean [SD] use, 1322 [1465] vs 1085 [1230] days) ( Table ). The crude hazard ratio for serous ovarian carcinoma was 0.22 (95% CI, 0.05-0.95); for breast cancer, it was 0.99 (95% CI, 0.84-1.17). For aim 2, 26 ovarian carcinomas were identified in individuals without fallopian tubes, with only 6 of 26 (23.1%) being HGSC compared with 642 of 942 (68.1%) in a historical cohort with fallopian tubes (Fisher exact test,  P  < .001) ( Figure ). 5\nAbbreviations: OCP, oral contraceptive pill; NA, not applicable; SMD, standardized mean difference.\nBased on census-based province-wide distribution.\nAmong OCP users.\nHazard ratio, 0.22 (95% CI, 0.05-0.95).\nCell sizes 1 through 5 are suppressed according to privacy requirements of the data stewards. These numbers must be reported as ≤5.\nHazard ratio, 0.99 (95% CI, 0.84-1.17).\nThe dark blue bars represent the historical distribution of ovarian cancers in women who have not had an opportunistic bilateral salpingectomy, as determined by Kobel et al. 5  The orange bars represent the expected numbers of ovarian cancers following a hypothetical application of an 80% reduction to the high-grade serous carcinoma histotype. The light blue bars indicate the actual observed ovarian cancers from patients who had undergone bilateral salpingectomy. The high-grade serous carcinoma (HGSC) histotype was significantly decreased in the observed cohort (23.1% of ovarian cancer cases) following bilateral salpingectomy compared with the historical histotype distribution of HGSC (68.1% of all ovarian carcinoma cases). Fisher exact test,  P  < .001. CCOC indicates clear cell ovarian carcinoma; ENOC, endometrioid ovarian carcinoma; LGSC, low-grade serous carcinoma; MUC, mucinous ovarian cancer.\n\nIn this expanded analysis of health care and cancer data from British Columbia, we add to preliminary evidence of effectiveness of OBS 6  as individuals who underwent OBS were at nearly 80% reduced risk for serous ovarian cancers compared with those who had a hysterectomy alone or tubal ligation. Our second aim showed significantly fewer HGSCs in people without fallopian tubes compared with the historical histotype distribution for ovarian carcinoma.\nLimitations include that many of these surgical procedures occurred in people well below the age of peak risk for HGSC, which resulted in a small number of ovarian carcinomas. This meant we could not control for all possible confounders in the Cox proportional hazards models. Nonetheless, these findings provide robust support for the effectiveness of OBS as a preventive intervention and underscore that broader implementation of OBS has the potential to significantly reduce the incidence and mortality of serous ovarian carcinoma.","source_license":"CC-BY-4.0","license_restricted":false}