{"paper_id":"e9b74928-69de-4481-b90e-b1e34651362d","body_text":"Abstract\nSeveral in vitro models that attempt to replicate the intraperitoneal environment have been developed to study the pathogenesis of endometriosis. The chicken chorioallantotic membrane has been used, but it has not been well characterized and may introduce some species specific variables. In vitro models using human tissues include amniotic membrane, human peritoneal explants, and cell culture monolayers. These models have been used to qualitatively, quantitatively, and temporally assess attachment of endometrial cells to peritoneal mesothelial and subsequent transmesothelial invasion. These models have also been used to assess the role of cytokines in the development of the early endometriotic lesion. Two- and three dimensional invasion chamber models have been utilized to assess endometrial cell interactions with peritoneal mesothelial cells and the extracellular matrix. 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In Vitro Models to Study the Pathogenesis of Endometriosis. Reprod. Sci. 17, 5–12 (2010). https://doi.org/10.1177/1933719109338221\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719109338221","source_license":"CC0","license_restricted":false}