{"paper_id":"e82bcf6b-f9e3-4d71-9e58-b95b10405e5c","body_text":"Abstract\nObjectives\nTo evaluate the diagnostic performance of quantitative values and MRI findings for differentiating seromucinous borderline tumours (SMBTs) from endometriosis-related malignant ovarian tumours (MT).\nMethods\nThis retrospective study examined 19 lesions from SMBT and 84 lesions from MT. The following quantitative values were evaluated using receiver-operating characteristic analysis: overall and solid portion sizes, fluid signal intensity (SI), degree of contrast-enhancement, and mean and minimum apparent diffusion coefficient (ADC) values of the solid portion. Two radiologists independently evaluated four MRI findings characteristic of SMBT, fluid SI on the T1-weighted image and SI of the solid portion on diffusion-weighted image. The diagnostic values of these findings and interobserver agreement were assessed.\nResults\nFor diagnosing SMBT, the mean ADC value of the solid portion showed the greatest area under the curve (0.860) (cut-off value: 1.31 × 10-3 mm2/s, sensitivity: 1.00, specificity: 0.61). The T2-weighted image (T2WI) high SI solid portion was the most useful finding, with high specificity and interobserver agreement (sensitivity, 0.58; specificity, 0.95–0.96, kappa = 0.96), followed by T2WI low SI core (sensitivity, 0.48–0.63; specificity, 0.98, kappa = 0.68).\nConclusion\nMean ADC values of the solid portion, T2WI high SI solid portion, and T2WI low SI core were useful for differentiating SMBT from MT.\nKey Points\n• SMBT is a newly categorised ovarian tumour often associated with endometriosis.\n• Differentiation of SMBT from endometriosis-related malignant ovarian tumour is clinically important.\n• Diagnostic performances of quantitative values and MRI findings were evaluated.\n• Mean ADC value of the solid portion was the most useful value.\n• “T2WI high SI solid portion” was the most useful MRI finding.\nSimilar content being viewed by others\nAbbreviations\n- MMBT:\n-\nMüllerian mucinous borderline tumour\n- MEBT:\n-\nMüllerian mixed epithelial borderline tumour\n- SMBT:\n-\nSeromucinous borderline tumour\n- CCC:\n-\nClear cell carcinoma\n- EC:\n-\nEndometrioid carcinoma\n- DWI:\n-\nDiffusion-weighted image\n- ADC:\n-\nApparent diffusion coefficient\n- SI:\n-\nSignal intensity\nReferences\nKurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) WHO classification of tumours of female reproductive organs. 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Radiology 212:333–339\nThomassin-Naggara I, Daraï E, Cuenod CA et al (2008) Dynamic contrast-enhanced magnetic resonance imaging: a useful tool for characterizing ovarian epithelial tumors. J Magn Reson Imaging 28:111–120\nAcknowledgements\nThe scientific guarantor of this publication is Aki Kido. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board.\nMethodology: retrospective, diagnostic or prognostic study, performed at one institution.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nKurata, Y., Kido, A., Moribata, Y. et al. Diagnostic performance of MR imaging findings and quantitative values in the differentiation of seromucinous borderline tumour from endometriosis-related malignant ovarian tumour. Eur Radiol 27, 1695–1703 (2017). https://doi.org/10.1007/s00330-016-4533-x\nReceived:\nRevised:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00330-016-4533-x","source_license":"CC0","license_restricted":false}