{"paper_id":"e6acd8f2-071b-4052-a2da-1468bbf3cc08","body_text":"Endometriose: evolução das terapias e intervenções cirúrgicas modernas\nDOI:\nhttps://doi.org/10.55905/cuadv16n8-020Palavras-chave:\ndor pélvica, infertilidade, terapias combinadas, medicina de precisãoResumo\nA endometriose é uma condição ginecológica crônica caracterizada pela presença de tecido endometrial fora da cavidade uterina, afetando milhões de mulheres em idade reprodutiva globalmente. Este estudo revisa a eficácia das terapias farmacológicas e das intervenções cirúrgicas modernas no tratamento da endometriose, analisando seu impacto na qualidade de vida das pacientes, bem como os custos e a acessibilidade desses tratamentos. A metodologia envolveu uma Revisão Integrativa da Literatura, utilizando operadores booleanos para buscar dados em bases como PubMed, LILACS e Scopus. Os resultados indicam que as terapias hormonais, como os agonistas do GnRH e os contraceptivos orais combinados, são eficazes na redução dos sintomas, mas estão associadas a efeitos colaterais significativos e alta taxa de recorrência. As intervenções cirúrgicas, especialmente a laparoscopia, mostram benefícios na remoção de lesões endometrióticas e na melhora das taxas de fertilidade, embora a recorrência pós-cirúrgica continue sendo um desafio. O desenvolvimento de terapias biológicas e o uso de fitoterápicos emergem como promissoras alternativas terapêuticas, necessitando de mais pesquisas para validar sua eficácia e segurança.\nReferências\nABRAMIUK, M. et al. The Role of the Immune System in the Development of Endometriosis. Cells, v. 11, n. 13, p. 2028, 2022. DOI: https://doi.org/10.3390/cells11132028\nALEXANDER, P. et al. Benefits of Surgical Intervention in Women with Endometriosis-Related Infertility. Endometriosis, v. 5, 2020. 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