{"paper_id":"e4b19fb2-6679-4186-a961-1db0e8367729","body_text":"Note! Please note that this article is currently in the \"Early View\" stage and is not the final \"Version of record\". While it has been accepted, copy-edited, and formatted, however, it is still undergoing proofreading and corrections by the authors. Therefore, the text may still change before the final publication. Although \"Early View\" may not have all bibliographic details available, the DOI and the year of online publication can still be used to cite them. The article title, DOI, publication year, and author(s) should all be included in the citation format. Once the final \"Version of record\" becomes available the \"Early View\" will be replaced by that.\nAbstract\nDiseases of the female reproductive system are prevalent. These conditions often have\na high proportion of asymptomatic patients and prolonged treatment durations. Estrogen, a crucial\nsteroid hormone, plays a central role in most diseases of the female reproductive system. It is essential\nfor promoting the development of reproductive organs and follicular growth, maintaining\nregular menstrual cycles, and supporting pregnancy. The expression levels of estrogen-related receptors\nand circulating estrogen levels are closely linked to various female reproductive disorders.\nHowever, most diseases of the female reproductive system lack specific therapeutic drugs, and estrogen\ntherapy is still primarily used as a monotherapy. The clinical application of hormone-targeted\ntherapies remains immature. In light of these challenges, this review focuses on the effects of\nestrogen and estrogen-related receptors on common diseases of the female reproductive system.\nThis review provides an overview of the pathogenesis and therapeutic mechanisms of four common\ngynecological disorders: endometriosis (EMS), abnormal uterine bleeding (AUB), polycystic\novary syndrome (PCOS), and premature ovarian insufficiency (POI). This study aims to identify\nnovel target receptors and provide insights for estrogen-based therapies in the treatment of diseases\nof the female reproductive system.\nKeywords: Estrogen, estrogen-related receptors, diseases of the female reproductive system, treatment of gynecological diseases.\n7","source_license":"CC0","license_restricted":false}