{"paper_id":"e2580f7e-8aab-4dc7-b542-0fa1bd6ec097","body_text":"Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT)\nDate\n2007\nJournal Title\nJournal ISSN\nVolume Title\nPublisher\nHealth & Medical Publishing Group\nAbstract\nObjective. To determine whether active pelvic endometriosis impairs the efficacy of GIFT (gamete intrafallopian\ntransfer) and whether prior surgical treatment of endometriosis improves the efficacy of GIFT.\nDesign. Matched controlled retrospective study.\nSetting. University-based assisted reproduction programme.\nPatients. Patients who had GIFT between 1990 and 1997 were included in the study. Female patients\nwere laparoscopically diagnosed as having endometriosis. Patients who did not have surgical treatment for\nendometriosis before GIFT were staged for endometriosis during the GIFT laparoscopy. Two patients, with\nno signs of endometriosis, were matched for every endometriosis case, and served as controls. Patients were\nmatched for age, number of eggs transferred and percentage of normal sperm morphology.\nIntervention. Patients in 80 cycles had surgical treatment for endometriosis and 128 patients had GIFT\nprocedures as treatment for endometriosis-related infertility.\nMain outcome measures. Ongoing pregnancies and deliveries.\nStatistical analysis. A Mantel-Haenszel approach was used to estimate relative risk of pregnancy outcome in\nthe endometriosis groups versus controls.\nResults. There was a 22.9% pregnancy rate (11/48) among patients with active endometriosis who had GIFT\nprocedures, versus a 37.0% pregnancy rate (37/100) for the controls, giving a relative risk of 0.62 (95% confidence\ninterval (CI): 0.35 - 1.10, p = 0.082). There was a 36.3% pregnancy rate (29/80) among patients who had surgical\ntreatment for endometriosis before GIFT, versus a 33.3% pregnancy rate (53/159) for the controls, giving a relative\nrisk of 1.07 (95% CI: 0.75 - 1.54, p = 0.647).\nConclusion. There is an indication that GIFT pregnancy rates are impared in patients suffering from active\nendometriosis, while prior surgery may alleviate the impairment.\nDescription\nCITATION: Van der Merwe, J. P., Kruger, T. F. & Lombard, C. J. 2007. Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT). South African Journal of Obstetrics and Gynaecology, 13(1):42-44.\nThe original publication is available at http://www.sajog.org.za\nThe original publication is available at http://www.sajog.org.za\nKeywords\nEndometriosis\nCitation\nVan der Merwe, J. P., Kruger, T. F. & Lombard, C. J. 2007. Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT). South African Journal of Obstetrics and Gynaecology, 13(1):42-44.","source_license":"CC0","license_restricted":false}