{"paper_id":"e06e4073-e1a4-463c-82ca-83d148f0eadd","body_text":"INTRODUCTION \nReview question / Objective The review \naims to identify risk factors associated with \nrecurrence of endometriosis and pregnancy \ngain after surgery.\nP: Ovarian endometriosis patients after surgery I: \nNo artificial intervention C:Patients without \nrecurrence or without pregnancy O: Recurrence of \nendometriosis or pregnancy S:Randomized \ncontrolled study, cohort study or case-controlled \nstudy. \nRationale Ovarian endometriosis is a refractory \ndisease in gynecology that has high recurrent rate \nand infertility rate. We aim to summarize published \narticles associated with the topic to evaluate risk \nfactors. This can help clinical practice in the future. \nCondition being studied Endometriosis, also \nknown as endometrioma, is a complex disease \nwith unclear etiologies. The manifestations of the \ndisease include dysmenorrhea, infertility and pelvic \npain. Surgery and hormone therapy are the main \ntherapies of endometriosis. \nMETHODS \nSearch strategy MeSH terms of \"risk factors\", \n“endometriosis\", \"pregnancy\", \"recurrence\" and \ntheir free texts are applied. Pubmed, Embase, Web \nof Science, CNKI, Wanfang and Weipu are \nsearched. \nParticipant or population Ovarian endometriosis \npatients after surgery. \nIntervention No artificial intervention. \nComparator Patients without recurrence or \nwithout pregnancy. \nStudy designs to be included Randomized \ncontrolled study, cohort study or case-controlled \nstudy. \nINPLASY 1\nInternational Platform of Registered Systematic Review and Meta-analysis Protocols\nINPLASYIdentification of risk factors associated with \nendometriosis recurrence and pregnancy after surgery\nZhao, XJ; Liu, Y; Wang, L.\nADMINISTRATIVE INFORMATION  \nSupport -  Zhejiang Traditional Chinese Medicine Administration. \nReview Stage at time of this submission - Preliminary searches. \nConflicts of interest - None declared. \nINPLASY registration number: INPLASY202590055 \nAmendments - This protocol was registered with the International \nPlatform of Registered Systematic Review and Meta-Analysis Protocols \n(INPLASY) on 14 September 2025 and was last updated on 14 \nSeptember 2025.\nCorresponding author: \nLiang Wang\n2196042@zju.edu.cn\nAuthor Affiliation:                   \nThe Second Affiliated Hosptial, \nZhejiang University School of \nMedicine.\nZhao et al. INPLASY protocol 202590055. doi:10.37766/inplasy2025.9.0055\nZhao et al. INPLASY protocol 202590055. doi:10.37766/inplasy2025.9.0055 Downloaded from https://inplasy.com/inplasy-2025-9-0055/\nINPLASY202590055\ndoi: 10.37766/inplasy2025.9.0055 \nReceived: 14 September 2025\nPublished: 14 September 2025\n\nEligibility criteria All articles that are associated \nwith endometriosis recurrence risk factors or \ninfertility risk factors are included.\nExclusion criteria: 1. Reviews, meta-analysis, \nthesis, editorial and other non-article publications, \n2. Case report, 3. Animal studies or in-vitro \nstudies, 4. Articles that are not written in English or \nChinese, 5. Articles that are not associated with \nendometriosis or recurrence risk factors or \ninfertility risk factors. \nInformation sources Electronic databases: \nPubmed, Embase, Web of Science, Cochrane \nLibrary, CNKI, Wanfang and Weipu.\nMain outcome(s) Recurrence situation or \npregnancy situation. \nQuality assessment / Risk of bias analysis \nRandomized controlled studies are evaluated by \nRoB 2. Non-RCT studies are evaluated by NOS \nscale. \nStrategy of data synthesis Continuous variables \nare synthesized in the form of mean, standard \ndeviation and sample sizes and analyzed by \nmetan. Categorical variables are synthesized in the \nform of positive number and negative number and \nanalyzed by metan. Effect value are synthesized \nand analyzed by midas.\nSubgroup analysis Subgroup analysis are \nconducted if various variables are available in the \nsame outcomes. \nSensitivity analysis Sensitivity analysis is \nconducted by metaninf if applicable. \nLanguage restriction English or Chinese. \nCountry(ies) involved China. \nKeywords Endometriosis; Recurrence; Pregnancy; \nRisk factors. \nContributions of each author \nAuthor 1 - Xiaojing Zhao - Author 1 searched the \ndatabase, selected articles and will analyze result \nand draft the manuscript.\nEmail: 22318652@zju.edu.cn\nAuthor 2 - Yang Liu - Author 2 will selected articles.\nEmail: liuyangzheda@zju.edu.cn\nAuthor 3 - Liang Wang - Author 3 raised the idea \nand will revise the manuscript.\nEmail: 2196042@zju.edu.cn\nINPLASY 2Zhao et al. INPLASY protocol 202590055. doi:10.37766/inplasy2025.9.0055\nZhao et al. INPLASY protocol 202590055. doi:10.37766/inplasy2025.9.0055 Downloaded from https://inplasy.com/inplasy-2025-9-0055/","source_license":"CC0","license_restricted":false}