{"paper_id":"e00cd13f-f5c8-4e85-8d76-883cc5db4973","body_text":"EN\nThe Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis\nAbstract\nBackground and objectives\nEndometriosis occurs in about 5-10 in 100 women of reproductive age. The pathophysiology of endometriosis is controversial. Some studies claimed an association between endometriosis and increased levels of inflammatory factors in peritoneal fluid and/or peripheral blood. Monocyte / HDL cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) are inflammatory markers and are used as predictors and prognostic indicators of mortality and morbidity in many diseases. In this study, we aimed to investigate whether Monocyte / HDL cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) are increased in endometriosis as in patients with chronic inflammation and cardiovascular diseases.\nMaterials and Methods\nThis is a retrospective case-control study conducted with 87 women, 45 in the endometriosis group and 42 in the control group. The demographic data, biochemical, complete blood count parameters and lipid profile of the cases were recorded and compared between the groups.\nResults\nThe mean age of the endometriosis group was 33.88 years and was older than the control group. In terms of other demographic data, there were no difference between the two groups. Although the platelet distribution width and triglyceride values of the endometriosis group were higher than controls, they were interpreted as clinically insignificant. There were no significant differences between the groups in terms of other laboratory parameters including MHR and NLR.\nConclusions\nIn this study, MHR and NLR are found similar in endometriosis and control groups. Further studies are needed to investigate the relationship between increased systemic inflammation.\nKeywords\nReferences\n- Abrao, M.S., Podgaec, S., Filho, B.M., Ramos, LO., Pinotti, JA., de Oliveira, R.M., 1997. The use of biochemical markers in the diagnosis of pelvic endometriosis. Hum Reprod. 12, 2523– 2527.\n- Akoum, A., Lemay, A., Paradis, I., 1996. Secretion of interleukin-6 by human endometriotic cells and regulation by proinflammatory cytokines and sex steroids. Hum Reprod. 11, 2269– 2275.\n- Auffray, C., Sieweke, M.H., Geissmann, F., 2009. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 27, 669–92.\n- Aydin, E,. Ates, I., Fettah Arikan, M., Yilmaz, N., Dede, F., 2017. The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension. Hypertens Res. 40, 758–64.\n- Barrier, B.F, 2010. Immunology of endometriosis. Clin Obstet Gynecol. 53, 397-402.\n- Bedaiwy, M.A., Falcone, T., Sharma, R.K., Goldberg, J.M., Attaran, M., Nelson, D.R, Agarwal, A., 2002. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 17, 426–431.\n- Canpolat, U., Çetin, E.H., Cetin, S., Aydin, S., Akboga, M.K., Yayla, C., Turak, O., Aras, D., Aydogdu S., 2016. Association of Monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation. Clin Appl Thromb. 22, 476–82.\n- Coutinho, LM., Ferreira, M.C., Rocha, A.L.L., Carneiro, M.M., Reis, F.M., 2019. New biomarkers in endometriosis. Adv Clin Chem. 89, 59–77.\nDetails\nPrimary Language\nEnglish\nSubjects\nHealth Care Administration\nJournal Section\nResearch Article\nPublication Date\nApril 3, 2021\nSubmission Date\nMay 18, 2020\nAcceptance Date\nNovember 5, 2020\nPublished in Issue\nYear 2021 Volume: 38 Number: 2\nAPA\nBiyik, İ., Keskin, F., & Saz, N. (2021). The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis. Deneysel Ve Klinik Tıp Dergisi, 38(2), 106-110. https://izlik.org/JA58NG26NT\nAMA\n1.Biyik İ, Keskin F, Saz N. The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis. J. Exp. Clin. Med. 2021;38(2):106-110. https://izlik.org/JA58NG26NT\nChicago\nBiyik, İsmail, Fatih Keskin, and Nagihan Saz. 2021. “The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Increased Systemic Inflammation and the Risk of Cardiovascular Disease in Endometriosis”. Deneysel Ve Klinik Tıp Dergisi 38 (2): 106-10. https://izlik.org/JA58NG26NT.\nEndNote\nBiyik İ, Keskin F, Saz N (April 1, 2021) The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis. Deneysel ve Klinik Tıp Dergisi 38 2 106–110.\nIEEE\n[1]İ. Biyik, F. Keskin, and N. Saz, “The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis”, J. Exp. Clin. Med., vol. 38, no. 2, pp. 106–110, Apr. 2021, [Online]. Available: https://izlik.org/JA58NG26NT\nISNAD\nBiyik, İsmail - Keskin, Fatih - Saz, Nagihan. “The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Increased Systemic Inflammation and the Risk of Cardiovascular Disease in Endometriosis”. Deneysel ve Klinik Tıp Dergisi 38/2 (April 1, 2021): 106-110. https://izlik.org/JA58NG26NT.\nJAMA\n1.Biyik İ, Keskin F, Saz N. The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis. J. Exp. Clin. Med. 2021;38:106–110.\nMLA\nBiyik, İsmail, et al. “The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Increased Systemic Inflammation and the Risk of Cardiovascular Disease in Endometriosis”. Deneysel Ve Klinik Tıp Dergisi, vol. 38, no. 2, Apr. 2021, pp. 106-10, https://izlik.org/JA58NG26NT.\nVancouver\n1.İsmail Biyik, Fatih Keskin, Nagihan Saz. The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis. J. Exp. Clin. Med. [Internet]. 2021 Apr. 1;38(2):106-10. Available from: https://izlik.org/JA58NG26NT","source_license":"CC0","license_restricted":false}