{"paper_id":"df877c50-6677-479a-addb-8b0c0f1a71e1","body_text":"Abstract\nThe current study aimed to identify and validate an applicable immunohistochemistrypanelincluding Ki-67, c-MYC, estrogen receptor-α (ER-α), and progesterone receptor isoforms A/B (PR-A/B) in correlation with clinicopathological parameters in patients affected by deep infiltrating endometriosis. Tissue microarrays were prepared from a cohort of I 13 patients. Phenotypic profile of the panel molecules was evaluated in glands and stroma in parallel with microvessels and stroma density measurements. Principal component analysis was performed on 8 immunohistochemical variables, 2 histological variables, and 8 subgroups of clinical parameters. The immunohistochemical profiling showed consistent Ki-67 immunostaining in 17.9% of the samples and c-MYC in 83.1%, while intense ER-a immunoreactivity was detected in 84% of the samples and PR-A/B isoforms in 24.1% of them. 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Sci. 23, 1258–1268 (2016). https://doi.org/10.1177/1933719116638188\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719116638188","source_license":"CC0","license_restricted":false}