{"paper_id":"df35b06d-f775-4c20-8b6f-b371f8e6ae78","body_text":"Breaking the Pain Cycle: Amplifier Loops, Central Sensitization, and a CSI-Guided Clinical Decision Framework — A Scoping Review\nAuthors/Creators\n- 1. Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain\nDescription\nThis scoping review (PRISMA-ScR) maps the major amplifier loops sustaining central sensitization in chronic pain and proposes a CSI-guided clinical decision framework. The article includes 59 verified references, Table 1 (IASP Diagnostic Integration and Loop-Targeted Sequencing), Table 2 (Impact of Preoperative CSI on IMMPACT Core Outcome Domains Across Surgical and Interventional Procedures), and two figures (Clinical Decision Tree and PRISMA-ScR Flow Diagram). Version 3 adds Section 5.3 analyzing how preoperative CSI scores predict IMMPACT outcomes across knee/hip arthroplasty, spine surgery, endometriosis surgery, and functional restoration programs.\nFiles\nFiles\n(56.9 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:05c0ce9622aeb67b27f69cc09965dbcd\n|\n56.9 kB | Download |","source_license":"CC0","license_restricted":false}