{"paper_id":"de9b40fd-07b9-472f-be41-857a22572cda","body_text":"Abstract\nWhile endometriosis has been historically considered a disease affecting reproductive aged women, the disease can frequently occur in adolescents as well. Adolescents with endometriosis may be asymptomatic or have debilitating and distressing symptoms, interfering with school and social activities. Many adult women experience their endometriosis symptoms starting in adolescence, but most young women do not receive timely treatment. Thus, clinicians should be aware of how endometriosis may present in adolescents in order to proceed with prompt evaluation and treatment. Early prevention in adolescence may help mitigate the long-term sequelae of endometriosis including chronic pelvic pain and infertility.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nMeigs JV. Endometriosis. Ann Surg. 1948;127(5):795–808.\nLaufer MR, Goitein L, Bush M, et al. Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J Pediatr Adolesc Gynecol. 1997;10(4):199–202.\nReese KA, Reddy S, Rock JA. Endometriosis in an adolescent population: the Emory experience. J Pediatr Adolesc Gynecol. 1996;9(3):125–8.\nGoldstein DP, De Cholnoky C, Emans SJ. Adolescent endometriosis. J Adolesc Health Care. 1980;1(1):37–41.\nJanssen EB, Rijkers ACM, Hoppenbrouwers K, et al. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570–82.\nRagab A, Shams M, Badawy A, et al. Prevalence of endometriosis among adolescent school girls with severe dysmenorrhea: a cross sectional prospective study. Int J Health Sci (Qassim). 2015;9(3):273–81.\nFong YF, Hon SK, Low LL, et al. The clinical profile of young and adolescent women with laparoscopically diagnosed endometriosis in a Singapore tertiary hospital. Taiwan J Obstet Gynecol. 2017;56(2):181–3.\nAl-Jefout M, Alnawaiseh N, Yaghi S, et al. Prevalence of endometriosis and its symptoms among young Jordanian women with chronic pelvic pain refractory to conventional therapy. J Obstet Gynaecol Can. 2018;40(2):165–70.\nHirsch M, Dhillon-Smith R, Cutner AS, et al. The prevalence of endometriosis in adolescents with pelvic pain: a systematic review. J Pediatr Adolesc Gynecol. 2020;S1083–3188(2):30287–4.\nStaal AHJ, van der Zanden M, Nap AW. Diagnostic delay of endometriosis in the Netherlands. Gynecol Obstet Investig. 2016;81(4):321–4.\nNnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373.e8.\nSoliman AM, Fuldeore M, Snabes MC. Factors associated with time to endometriosis diagnosis in the United States. J Womens Health (Larchmt). 2017;26(7):788–97.\nHudelist G, Fritzer N, Thomas A, et al. Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod. 2012;27(12):3412–6.\nAgarwal SK, Chapron C, Giudice LC, et al. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019;220(4):354.e1–354.e12.\nBallweg ML. Big picture of endometriosis helps provide guidance on approach to teens: comparative historical data shows endo starting younger, is more severe. J Pediatr Adolesc Gynecol. 2003;16(3 Suppl):S21–6.\nMarsh EE, Laufer MR. Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly. Fertil Steril. 2005;83(3):758–60.\nGoldstein DP, de Cholnoky C, Leventhal JM, Emans SJ. New insights into the old problem of chronic pelvic pain. J Pediatr Surg. 1979;14(6):675–80.\nYamamoto K, Mitsuhashi Y, Takaike T, et al. Tubal endometriosis diagnosed within one month after menarche: a case report. Tohoku J Exp Med. 1997;181(3):385–7.\nSimpson JL, Elias S, Malinak LR, et al. Heritable aspects of endometriosis. I. Genetic studies. Am J Obstet Gynecol. 1980;137(3):327–31.\nHansen KH, Eyster KM. Genetics and genomics of endometriosis. Clin Obstet Gynecol. 2010;53(2):403–12.\nKennedy S, Hadfield R, Mardon H, et al. Age of onset of pain symptoms in non-twin sisters concordant for endometriosis. Hum Reprod. 1996;11(2):403–5.\nDovey S, Sanfilippo J. Endometriosis and the adolescent. Clin Obstet Gynecol. 2010;53(2):420–8.\nSchifrin BS, Erez S, Moore JG. Teen-age endometriosis. Am J Obstet Gynecol. 1973;116(7):973–80.\nOlive DL, Henderson DY. Endometriosis and Mullerian anomalies. Obstet Gynecol. 1987;69(3 Pt 1):412–5.\nSanfilippo JS, Wakim NG, Schikler KN, et al. Endometriosis in association with uterine anomaly. Am J Obstet Gynecol. 1986;154(1):39–43.\nSilveira SA, Laufer MR. Persistence of endometriosis after correction of obstructive reproductive tract anomaly. J Pediatr Adolesc Gynecol. 2010;23:e89.\nNnoaham KE, Webster P, Kumbang J, et al. Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil Steril. 2012;98(3):702–712.e6.\nTreloar SA, Bell TA, Nagle CM, et al. Early menstrual characteristics associated with subsequent diagnosis of endometriosis. Am J Obstet Gynecol. 2010;202(6):534.e1–6.\nBallard KD, Seaman HE, de Vries CS, et al. Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study–Part 1. BJOG. 2008;115(11):1382–91.\nHediger ML, Hartnett HJ, Buck Louis GM. Association of endometriosis with body size and figure. Fertil Steril. 2005;84(5):1366–74.\nMissmer SA, Hankinson SE, Spiegelman D, et al. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol. 2004;160(8):784–96.\nBougie O, Healey J, Singh SS. Behind the times: revisiting endometriosis and race. Am J Obstet Gynecol. 2019;221(1):35.e1–5.\nHarris HR, Wieser F, Vitonis AF, et al. Early life abuse and risk of endometriosis. Hum Reprod. 2018;33(9):1657–68.\nShafrir AL, Farland LV, Shah DK, et al. Risk for and consequences of endometriosis: a critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018;51:1–15.\nSasamoto N, Farland LV, Vitonis AF, et al. In utero and early life exposures in relation to endometriosis in adolescents and young adults. Eur J Obstet Gynecol Reprod Biol. 2020;252:393–8.\nNodler JL, Harris HR, Chhavarro JE, et al. Dairy consumption during adolescence and endometriosis risk. Am J Obstet Gynecol. 2020;222(3):257.e1–257.e16.\nSampson JA. Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol. 1927;3(2):93–110.43.\nHalme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64(2):151–4.\nTsonis O, Barmpalia Z, Gkrozou F, et al. Endometriosis in adolescence: early manifestation of the traditional disease or a unique variant? Eur J Obstet Gynecol Reprod Biol. 2020;247:238–43.\nBrosens I, Gargett CE, Gou SW, et al. Origins and progression of adolescent endometriosis. Reprod Sci. 2016;23(1):1282–8.\nOber WB, Bernstein J. Observations on the endometrium and ovary in the newborn. Pediatrics. 1955;16(4):445–60.\nArcellana RC, Robinson TW, Tyson RW, et al. McKusick-Kaufman syndrome with legal complications of hydrometrocolpos and congenital endometriosis. J Perinatol. 1996;16(3):220–3.\nBrosens I, Gordts S, Benagiano G. Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion. Hum Reprod. 2013;28(8):2026–31.\nHalban J. Metastatic hysteroadenosis. Wien Klin Wochenschr. 1924;37:1205–6.\nMeyer R. Über entzundliche neterope Epithelwucherungen im weiblichen Genetalgebiet and über eine his in die Wurzel des Mesocolon ausgedehnte benigne Wucherung des Darmepithel. Virchows Arch Pathol Anat. 1909;195:487.\nBurney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98(3):511–9.\nBailey AP, Hill AS, Beste MT, et al. Comparison of cytokines in the peritoneal fluid and conditioned medium of adolescents and adults with and without endometriosis. Am J Reprod Immunol. 2020:e13347.\nDysmenorrhea and endometriosis in the adolescent. ACOG Committee Opinion No. 760. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2018;132:e249–58.\nDiVasta AD, Vitonis AF, Laufer MR, Missmer SA. Spectrum of symptoms in women diagnosed with endometriosis during adolescence vs adulthood. Am J Obstet Gynecol. 2018;218(3):324.e1–324.e11.\nAmerican Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis. 1997;67(5):817–21.\nSchneider MP, Vitonis AF, Fadayomi AB, et al. Quality of life in adolescent and young adult women with dyspareunia and endometriosis. J Adolesc Health. 2020;67(4):557–61.\nDun EC, Kho KA, Morozov VV, et al. Endometriosis in adolescents. JSLS. 2015;19(2):e2015.00019.\nButrick CW. Patients with chronic pelvic pain: endometriosis or interstitial cystitis/painful bladder syndrome? JSLS. 2007;11(2):182–9.\nSinaii N, Cleary SD, Ballweg ML, et al. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod. 2002;17(1):2715–24.\nDiVasta AD, Zimmerman LA, Vitonis AF, et al. Overlap between irritable bowel syndrome diagnosis and endometriosis in adolescents. Clin Gastroenterol Hepatol. 2020;S1542–3565(2):30324–4.\nMiller JA, Missmer SA, Vitonis AF, et al. Prevalence of migraines in adolescents with endometriosis. Fertil Steril. 2018;109(4):685–90.\nShim JY, Laufer MR. Adolescent endometriosis: an update. J Pediatr Adolesc Gynecol. 2020;33(2):112–9.\nShigesi N, Kvaskoff M, Kirley S, et al. The association between endometriosis and autoimmune diseases: a systematic review and meta-analyses. Hum Reprod Update. 2019;25(4):486–503.\nZannoni L, Giorgi M, Spagnolo E, et al. Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents. J Pediatr Adolesc Gynecol. 2014;27(5):258–65.\nGallagher JS, DiVasta AD, Vitonis AF, et al. The impact of endometriosis on quality of life in adolescents. J Adolesc Health. 2018;63(6):766–72.\nBallard K, Lowton K, Wright J. What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis. Fertil Steril. 2006;86(5):1296–301.\nGupta J, Cardoso LF, Harris CS. How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers? Findings from focus group discussions in New York City. BMJ Open. 2018;8(6):e020657.\nMama ST. Advances in the management of endometriosis in the adolescent. Curr Opin Obstet Gynecol. 2018;30(5):326–30.\nPatel DP. The evolving nomenclature of erythema Ab Igne-Redness from fire. JAMA Dermatol. 2017;153(7):685.\nTighe MP, Morenas RA, Afzal NA, et al. Erythema ab igne and Crohn’s disease. Arch Dis Child. 2008;93(5):389.\nGubbels A, Spivack L, Lindheim SR, et al. Adolescent endometriosis. Obstet Gynecol Surv. 2020;75(8):483–96.\nHirsch M, Duffy JMN, Deguara CS, et al. Diagnostic accuracy of Cancer Antigen 125 (CA125) for endometriosis in symptomatic women: a multi-center study. Eur J Obstet Gynecol Reprod Biol. 2017;210:102–7.\nSasamoto N, DePari M, Vitonis AF, et al. Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis. PLoS One. 2020;15(8):e0238043.\nMartire FG, Lazzeri L, Conway F, et al. Adolescence and endometriosis: symptoms, ultrasound signs and early diagnosis. Fertil Steril. 2020;114(5):1049–57.\nChandler TM, Maschan LS, Cooperberg PL, et al. Mullerian duct anomalies: from diagnosis to intervention. Br J Radiol. 2009;82(84):1034–42.\nMarjoribanks J, Ayeleke RO, Farquhar C, et al. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2015;2015(7):CD001751.\nHarel Z. Dysmenorrhea in adolescents and young adults: an update on pharmacological treatments and management strategies. Expert Opin Pharmacother. 2012;13(15):2157–70.\nDmitrovic R, Kunselman AR, Legro RS. Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial. Obstet Gynecol. 2012;119(6):1143–50.\nPropst AM, Laufer MR. Endometriosis in adolescents. Incidence, diagnosis and treatment. J Reprod Med. 1999;44(9):751–8.\nFedele L, Parazzini F, Bianchi S, et al. Stage and localization of pelvic endometriosis and pain. Fertil Steril. 1990;53(1):155–8.\nAudebert A, Lecointre L, Afors K, et al. Adolescent endometriosis: report of a series of 55 cases with a focus on clinical presentation and long-term issues. J Minim Invasive Gynecol. 2015;22(5):834–40.\nDavis GD, Thillet E, Lindemann J. Clinical characteristics of adolescent endometriosis. J Adolesc Health. 1993;14(5):362–8.\nDemco L. Mapping the source and character of pain due to endometriosis by patient-assisted laparoscopy. J Am Assoc Gynecol Laparosc. 1998;5(3):241–5.\nLaufer MR. Identification of clear vesicular lesions of atypical endometriosis: a new technique. Fertil Steril. 1997;68(4):739–40.\nLaufer MR. Helping “adult gynecologists” diagnose and treat adolescent endometriosis: reflections on my 20 years of personal experience. J Pediatr Adolesc Gynecol. 2011;24(5 Suppl):S13–7.\nAbbott J, Hawe J, Hunter D, et al. Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial. Fertil Steril. 2004;82(4):878–84.\nSutton CJ, Ewen SP, Whitelaw N, et al. Prospective, randomized, double-blind, controlled trial of lapser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. Fertil Steril. 1993;62(4):696–700.\nSong XC, Yu X, Luo M, et al. Clinical characteristics and postoperative symptoms of 85 adolescents with endometriosis. J Pediatr Adolesc Gynecol. 2020;33(5):519–23.\nPractice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis. Fertil Steril. 2014;101(4):927–35.\nCook AS, Rock JA. The role of laparoscopy in the treatment of endometriosis. Fertil Steril. 1991;55(4):663–80.\nWright J, Lotfallah H, Jones K, et al. A randomized trial of excision versus ablation for mild endometriosis. Fertil Steril. 2005;83(6):1830–6.\nRiley KA, Benton AS, Deimling TA, et al. Surgical excision versus ablation for superficial endometriosis-associated pain: a randomized controlled trial. J Minim Invasive Gynecol. 2019;26(1):71–7.\nHealy M, Ang WC, Cheng C. Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation. Fertil Steril. 2010;94(7):2536–40.\nYeung P Jr, Sinervo K, Winer W, et al. Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary? Fertil Steril. 2011;95(6):1909–12, 1912.e1.\nLaufer MR, Missmer SA. Does complete laparoscopic excision of endometriosis in teenagers really occur? Fertil Steril. 2011;96(3):e145, author reply e146.\nLaufer MR, Einarsson JI. Surgical management of superficial peritoneal adolescent endometriosis. J Pediatr Adolesc Gynecol. 2019;32(30):339–41.\nWright KN, Laufer MR. Endometriomas in adolescents. Fertil Steril. 2010;94(4):1529.e7–9.\nHart RJ, Hickey M, Maouris P, et al. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev. 2008;2:CD004992.\nHung YC, Westfal ML, Chang DC, et al. Lack of data-driven treatment guidelines and wide variation in management of chronic pelvic pain in adolescents and young adults. J Pediatr Adolesc Gynecol. 2020;33(4):349–353.e1.\nShakiba K, Bena JF, McGill KM, et al. Surgical treatment of endometriosis: a 7-year follow-up on the requirement for further surgery. Obstet Gynecol. 2008;111(6):1285–92.\nMacDonald SR, Klock SC, Milad MP. Long-term outcome of nonconservative surgery (hysterectomy) for endometriosis-associated pain in women <30 years old. Am J Obstet Gynecol. 1999;180(6 Pt 1):1360–3.\nDoyle JO, Missmer SA, Laufer MR. The effect of combined surgical-medical intervention on the progression of endometriosis in an adolescent and young adult population. J Pediatr Adolesc Gynecol. 2009;22(4):257–63.\nUnger CA, Laufer MR. Progression of endometriosis in non-medically managed adolescents: a case series. J Pediatr Adolesc Gynecol. 2011;24(2):e21–3.\nGolden NH. Bones and birth control in adolescent girls. J Pediatr Adolesc Gynecol. 2020;33(3):249–54.\nGallo MF, Nanda K, Grimes DA, et al. 20 μg versus >20 μg estrogen combined oral contraceptives for contraception. Cochrane Database Syst Rev. 2013;2013(8):CD003989.\nXulane- norelgestromin and ethinyl estradiol patch. US Food and Drug Administration (FDA) approved product information. Revised 2020. US National Library of Medicine. www.dailymed.nlm.nih.gov. Accessed on 2 Oct 2020.\nMilsom I, Korver T. Ovulation incidence with oral contraceptives: a literature review. J Fam Plann Reprod Health Care. 2008;34(4):237–46.\nSlynd (drospirenone tablets). US FDA approved product information; Florham Park: Exeltis USA, Inc; 2019. www.accessdata.fda.gov/drugsatfda_docs/label/2019/211367s000lbl.pdf. Accessed on 2 Oct 2020.\nBenagiano G, Primiero FM. Seventy-five microgram desogestrel minipill, a new perspective in estrogen-free contraception. Ann N Y Acad Sci. 2003;997:163–73.\nAygestin (norethindrone acetate). US FDA approved product information; Pomona: Duramed Pharmaceuticals, Inc; 2007. www.accessdata.fda.gov/drugsatfda_docs/label/2007/018405s023lbl.pdf. Accessed on 23 Nov 2020.\nBrady PC, Missmer SA, Laufer MR. Hepatic adenomas in adolescents and young women with endometriosis treated with norethindrone acetate. J Pediatr Adolesc Gynecol. 2017;30(3):422–4.\nChu MC, Zhang X, Gentzschein E, et al. Formation of ethinyl estradiol in women during treatment with norethindrone acetate. J Clin Endocrinol Metab. 2007;92(6):2205–7.\nKaser DJ, Missmer SA, Berry KF, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012;25(2):105–8.\nCromer BA, Smith RD, Blair JM, et al. A prospective study of adolescents who choose among levonorgestrel implant (Norplant), medroxyprogesterone acetate (Depo-Provera), or the combined oral contraceptive pill as contraception. Pediatrics. 1994;94(5):687–94.\nCarvalho N, Margatho D, Cursino K, et al. Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52-mg levonorgestrel-releasing intrauterine system: randomized clinical trial. Fertil Steril. 2018;110(6):1129–36.\nDarney P, Patel A, Rosen K, et al. Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials. Fertil Steril. 2009;91(5):1646–53.\nAbou-Setta AM, Al-Inany HG, Farquhar CM. Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. Cochrane Datatbase Syst Rev. 2006;4:CD005072.\nYoost J, LaJoie AS, Hertweck P, et al. Use of the levonorgestrel intrauterine system in adolescents with endometriosis. J Pediatr Adolesc Gynecol. 2013;26(2):120–4.\nKebodeaux CA, Schwartz BI. Experience with intrauterine device insertion in never sexually active adolescents: a retrospective cohort study. Am J Obstet Gynecol. 2018;219(6):600.e1–7.\nDmowski WP. Danazol in the treatment of endometriosis and infertility. Prog Clin Biol Res. 1982;112 Pt B:167–86.\nRock JA, Truglia JA, Caplan RJ. Zoladex (goserelin acetate implant) in the treatment of endometriosis: a randomized comparison with danazol. The Zoladex Endometriosis Study Group. Obstet Gynecol. 1993;82(2):198–205.\nSelak V, Farquhar C, Prentice A, et al. Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2001;4:CD000068.\nBoothroyd CV, Lepre F. Permanent voice change resulting from Danazol Therapy. Aust N Z J Obstet Gynaecol. 1990;30(3):275–6.\nTaub RL, Adriane ES, Neal-Perry G, et al. The effect of testosterone on ovulatory function in transmasculine individuals. Am J Obstet Gynecol. 2020;223(2):229.e1–8.\nGrimstad FW, Fowler KG, New EP, et al. Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series. Am J Obstet Gynecol. 2019;220(3):257.e1–7.\nShim JY, Laufer MR, Grimstad FW. Dysmenorrhea and endometriosis in transgender adolescents. J Pediatr Adolesc Gynecol. 2020;33(5):524–8.\nDiVasta AD, Feldman HA, Gallagher JS, et al. Hormonal add-back therapy for females treated with gonadotropin-releasing hormone agonist for endometriosis: a randomized controlled trial. Obstet Gynecol. 2015;126(3):617–27.\nGallagher JS, Feldman HA, Stokes NA, et al. The effects of gonadotropin-releasing hormone agonist combined with add-back therapy on quality of life for adolescents with endometriosis: a randomized controlled trial. J Pediatr Adolesc Gynecol. 2017;30(2):215–22.\nGallagher JS, Missmer SA, Hornstein MD, et al. Long-term effects of gonadotropin-releasing hormone agonists and add-back in adolescent endometriosis. J Pediatr Adolesc Gynecol. 2018;31(4):376–81.\nShebley M, Polepally AR, Nader A, et al. Clinical pharmacology of Elagolix: an oral gonadotropin-releasing hormone receptor antagonist for endometriosis. Clin Pharmacokinet. 2020;59(3):297–309.\nNg J, Chwalisz K, Carter DC. Dose-dependent suppression of gonadotropins and ovarian hormones by Elagolix in healthy premenopausal women. J Clin Endocrinol Metab. 2017;102(5):1683–91.\nTaylor HS, Giudice LC, Lessey BA, et al. Treatment of endometriosis-associated pain with Elagolix, an oral GnRH antagonist. N Engl J Med. 2017;377(1):28–40.\nWayne PM, Kerr CE, Schnyer RN, et al. Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women: results of a randomized sham-controlled trial. J Pediatr Adolesc Gynecol. 2008;21(5):247–57.\nMira TA, Buen MM, Borges MG, et al. Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis. Int J Gynaecol Obstet. 2018;143(1):2–9.\nPattanittum P, Kunyanone N, Brown J, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016;3(3):CD002124.\nGreco CD. Management of adolescent chronic pelvic pain from endometriosis: a pain center perspective. J Pediatr Adolesc Gynecol. 2003;16(3 Suppl):S17–9.\nEmans SJ. Emans, Laufer, Goldstein's pediatric & adolescent gynecology. 7th ed. Lippincott Williams & Wilkins; 2019.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nShim, J.Y., Laufer, M.R. (2022). Endometriosis in Adolescence. In: Oral, E. (eds) Endometriosis and Adenomyosis. Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_12\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-97236-3_12\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-97235-6\nOnline ISBN: 978-3-030-97236-3\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}