{"paper_id":"dde9d6ab-06c3-41e6-be5e-59e02349a874","body_text":"Abstract\nAromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase activity tended to be high in the proliferative cells compared to the secretory cells. Moreover, its enzyme activity was enhanced at the concentration of 0.1 or 1.0 µM of medroxyprogesterone acetate (MPA) and norethindrone (ENT) in all phases of menstrual cycle. MPA stimulated aromatase activity in the stromal cells more strongly than did ENT. These results may suggest that although aromatase in uterine endometrium is not regarded to be so much influenced by endogenous progesterone during menstruation, the increase of aromatase activity by progestogen added lead to the more differentiated endometrium.\nSimilar content being viewed by others\nReferences\nTseng L., Mazella J., Mann W.J., Chumas J. Estrogen synthesis in normal and malignant human endometrium. J. Clin. Endocrinol. Metab. 55: 1029, 1982.\nYamaki J., Yamamoto T., Okada H. Aromatization of androstenedione by normal and neoplastic endometrium of the uterus. J. Steroid Biochem. 22: 63, 1985.\nTseng L., Mazella J., Sun B. Modulation of aromatase activity in human endometrial stromal cells by steroids, tamoxifen and RU 486. Endocrinology 118: 1312, 1986.\nFleming H., Gurpide E. Growth characteristics of primary cultures of stromal cells from human endometrium. J. Steroid Biochem. 16: 717, 1982.\nYamamoto T., Sakai C., Yamaki J., Takamori K., Yoshiji S., Kitawaki J., Fujii M., Yasuda J., Honjo H., Okada H. Estrogen biosynthesis in human liver. A comparison of aromatase activity for C-19 steroids in fetal liver, adult liver and hepatoma tissues of human subjects. Endocrinol. Jpn. 31: 277, 1984.\nTseng L. Estrogen synthesis in human endometrial epithelial glands and stromal ceils. J. Steroid Biochem. 20: 877, 1984.\nBaxendale P.M., Reed M.J., James V.H.T. Inability of human endometrium or myometrium to aromatize androstenedione. J. Steroid Biochem. 14: 305, 1981.\nForney J.P., Milewich L., Chen G.T., Garlock J.L., Schwarz B.E., Edman C.D., MacDonald P.C. Aromatization of androstenedione to estrone by human adipose tissue in vitro. Correlation with adipose tissue mass, age and endometrial neoplasia. J. Clin. Endocrinol. Metab. 51: 192, 1981.\nSchweikert H.U., Milewich L., Wilson J. Aromatization of androstenedione by cultured human fibroblasts. J. Clin. Endocrinol. Metab. 43: 785, 1976.\nKitawaki J., Yamamoto T., Okada H. Induction of estradiol dehydrogenase activity in human uterine endometrium by synthetic steroids. J. Endocrinol. Invest. 11: 351, 1988.\nOkuda K. Steroid hormone concentrations in human endometrium and plasma (in Japanese). Acta Obst. Gynaec. Jpn. 33: 353, 1981.\nTseng J.K., Sun B., Tseng L. The effect of progestin on rabbit endometrial aromatase activity. J. Steroid Biochem. 29: 9, 1988.\nMuramatsu K., Kinoshita M., Kato T., Noda Y., Tominaga T. The microstructure of cultured human uterine endometrium (in Japanese). Adv. Obst. Gynec. 35: 363, 1983.\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nYamamoto, T., Shiroshita, K., Kitawaki, J. et al. The inductive effects of progestogens on aromatase activity in stromal cells of human uterine endometrium. J Endocrinol Invest 12, 201–204 (1989). https://doi.org/10.1007/BF03349962\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/BF03349962","source_license":"CC0","license_restricted":false}