{"paper_id":"dd1765b0-c09a-463f-bc5e-0c6cc4b52832","body_text":"Abstract\nKeywords: DNA methylation, epigenetics, reproduction, placenta, sperm, infertility, medically assisted reproduction, imprinted genes.\nCurrent Pharmaceutical Design\nTitle:DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science\nVolume: 20 Issue: 11\nAuthor(s): Rosamaria Calicchio, Ludivine Doridot, Francisco Miralles, Celine Mehats and Daniel Vaiman\nAffiliation:\nKeywords: DNA methylation, epigenetics, reproduction, placenta, sperm, infertility, medically assisted reproduction, imprinted genes.\nAbstract: DNA methylation is an important part of the epigenetic code governing gene expression. In human reproductive diseases, recent studies have shown the existence of deviations from the normal methylation profile at various genome loci. In this review, this type of epigenetic alterations is explored in pathological spermatogenesis, ovarian diseases, placental syndromes, such as preeclampsia and Intra- Uterine Growth Restriction, uterine diseases such as endometriosis, and putative pathophysiological effects of Assisted Reproductive Technologies. We review the notion of epigenetics, the technical methods available to analyze methylation, and the known associations between reproductive diseases and DNA methylation, focusing on human pathologies and on animal models when available. We show that imprinted genes control regions (ICRs) are a prominent and frequent target of methylation anomalies in reproductive disorders, but such alterations also affect non-imprinted genes. The mechanistic aspects of gene regulation in response to methylation anomalies are also discussed in this review when they have been investigated.\nExport Options\nAbout this article\nCite this article as:\nCalicchio Rosamaria, Doridot Ludivine, Miralles Francisco, Mehats Celine and Vaiman Daniel, DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science, Current Pharmaceutical Design 2014; 20 (11) . https://dx.doi.org/10.2174/13816128113199990517\n| DOI https://dx.doi.org/10.2174/13816128113199990517 |\nPrint ISSN 1381-6128 |\n| Publisher Name Bentham Science Publishers |\nOnline ISSN 1873-4286 |\nCall for Papers in Thematic Issues\nAccelerating Cancer Drug Discovery Using Artificial Intelligence and In Silico Methods\nArtificial intelligence and in silico methods speed up cancer drug discovery, transforming how new treatments are developed. 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To address these challenges, ...read more\n- Author Guidelines\n- Bentham Author Support Services (BASS)\n- Graphical Abstracts\n- Fabricating and Stating False Information\n- Research Misconduct\n- Post Publication Discussions and Corrections\n- Publishing Ethics and Rectitude\n- Increase Visibility of Your Article\n- Archiving Policies\n- Peer Review Workflow\n- Order Your Article Before Print\n- Promote Your Article\n- Manuscript Transfer Facility\n- Editorial Policies\n- Allegations from Whistleblowers\n- Announcements\nRelated Articles\nCurrent Topics in Medicinal Chemistry Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review\nCurrent Drug Targets Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer\nCurrent Medicinal Chemistry Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy\nCurrent Cancer Drug Targets Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review\nCurrent Pharmaceutical Design Enhancing the Cytotoxic Activity of Novel Targeted Therapies – Is There a Role for a Combinatorial Approach?\nCurrent Clinical Pharmacology Sirolimus Eluting Stent: A New Era in Interventional Cardiology?\nCurrent Pharmaceutical Design Translocator Protein (TSPO) Role in Aging and Alzheimer’s Disease\nCurrent Aging Science Advances in Molecular Therapeutic Approaches to Patients with Malignant Gliomas\nCurrent Signal Transduction Therapy Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological Studies of <i>Phaleria macrocarpa</i>: A Systematic Review\nThe Natural Products Journal Therapeutic Effects of Vitamin D in Asthma and Allergy\nMini-Reviews in Medicinal Chemistry Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments\nCurrent Topics in Medicinal Chemistry New Insights into Binding Interfaces of Coagulation Factors V and VIII and their Homologues - Lessons from High Resolution Crystal Structures\nCurrent Protein & Peptide Science Alzheimers Disease and n-3 Polyunsaturated Fatty Acids: Beneficial Effects and Possible Molecular Pathways Involved\nCurrent Signal Transduction Therapy Drugging Cell Cycle Kinases in Cancer Therapy\nCurrent Drug Targets Combating Childhood Cancer: Paediatric Patients Living with Neuroblastoma - Regulatory Ramifications and Roadblocks\nApplied Drug Research, Clinical Trials and Regulatory Affairs Perinatal Management of Fetal Tumors\nCurrent Pediatric Reviews Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia\nCurrent Drug Targets Lung Cancer: Are we up to the Challenge?\nCurrent Genomics Angiogenesis and Metastasis Inhibitors for the Treatment of Malignant Melanoma\nMini-Reviews in Medicinal Chemistry","source_license":"public-domain-us","license_restricted":false}