{"paper_id":"dab4f21f-6a7b-40d4-96b6-cf15201449bb","body_text":"Chronic pelvic pain is estimated to affect 1 in 7 women, or approximately 9 million women in the United States, with associated health care costs approaching $3 billion annually. 1  The vast majority of patients with chronic pelvic pain (CPP) do not seek treatment, and less than 20% consult a gynecologist. Approximately 20% to 40% of laparoscopies are done for CPP. 2\nIn the gynecologic literature, chronic pelvic pain is associated with endometriosis in 30% to 87% of cases. 3 – 9  Endometriosis has been regarded as one of the most common causes of chronic pelvic pain that affects an estimated 5 million women in the US. 10  A definitive diagnosis of endometriosis requires an operative laparoscopy evaluation. Even with new advances in treatment of this disease, the rate of recurrence remains as high as 50%. 11  To make matters worse, it is considered a progressive disease in more than 60% of patients. 12  This often leads to numerous surgeries, including laparoscopies and even hysterectomies. Treatment of endometriosis-related chronic pelvic pain remains challenging to clinicians and the results have not been satisfactory.\nAlthough endometriosis is very common, interstitial cystitis, which is emerging as a more common disorder than previously recognized, should also be considered. It is estimated that as many as 2.5 million women in the US may be suffering from interstitial cystitis, and until recently, interstitial cystitis was underdiagnosed as a cause of CPP. 13  Several possible reasons exist as to why interstitial cystitis has not been recognized as the cause of pelvic pain. First, gynecologic teaching traditionally does not focus on syndromes originating from the bladder. Likewise, urologic and gastrointestinal training has not focused on pelvic pain syndromes. 14\nIn this study, we verified the association of the 2 diseases in patients with chronic pelvic pain and suggest that laparoscopy and cystoscopy/hydrodistention should be performed initially to avoid unnecessary delay in making the diagnosis of the two most common conditions in chronic pelvic pain syndromes.\n\nFrom October 1999 to October 2000, 60 women from ages 19 to 62 presented to the Midwest Regional Center for Chronic Pelvic Pain with complaints including dyspareunia and dysmenorrhea, with or without urinary symptoms like urinary frequency, urgency, nocturia, hesitancy, and sensation of incomplete emptying for more than 6 months of duration. They all underwent a physical examination with findings including abdominal-pelvic tenderness, uterine tenderness, and bladder tenderness. Laboratory studies included negative urine cytology and urine and genital cultures. The gynecology and urology teams then performed concurrent laparoscopic, cystoscopic, and hydrodistention evaluations. Intraoperative laparoscopic findings were not revealed to the urologists at the time of surgery. The urologist performed cystoscopy and hydrodistention after the laparoscopic evaluation was completed.\nAn endometriosis diagnosis was confirmed by biopsy, and the disease was treated by surgical excision. An inter-stitial cystitis diagnosis was made according to NIH guidelines, including the presence of glomerulation and terminal hematuria by either one of the urologists. The urologic procedure was carried out with sterile water under 80 to 100 cm of hydrostatic pressure; the bladder was distended for at least 2 minutes. The study results were then obtained from operative reports and chart reviews.\n\nIn the study group of 60 patients with chronic pelvic pain, 58 (96.6%) were diagnosed with interstitial cystitis with the presence of glomerulation and terminal hematuria by the urologists according to NIH criteria.\nA diagnosis of endometriosis was found in 56 patients, whereas 8 patients (14%) had a history of endometriosis but with a negative finding in the current laparoscopy evaluation. Forty-eight patients (80%) had biopsy-confirmed active lesions at surgery. Over 80% of patients had both diseases at the same time.\nForty-five patients (75%) with chronic pelvic pain had irritable urinary symptoms. In the interstitial cystitis group of 58 patients, 45 (77.5%) had urinary symptoms; and in the endometriosis group, 43 (76.5%) had urinary symptoms. This finding indicated that at least 25% of all study patient groups had no urinary symptoms.\nIn the interstitial cystitis group (58 patients), 47 patients (81%) had biopsy-confirmed active endometriosis, and 7 (12%) had a history of endometriosis but a negative laparoscopy in the current evaluation.\nIn the group of 56 patients diagnosed with either a history of or active endometriosis, 54 (96.4%) were also found to have interstitial cystitis on cystoscopy and hydrodistention. In the biopsy-confirmed active endometriosis group of 48 patients, 47 (97.7%) had interstitial cystitis.\nIn the patient group with negative laparoscopy findings, the majority improved in their symptoms after a cystoscopy/hydrodistention, which indicated that interstitial cystitis could have been the cause of their pelvic pain and not endometriosis despite their previous history of the disease.\n\nPatients with chronic pelvic pain syndrome are difficult to manage. Endometriosis has been considered the most common diagnosis in women with CPP. At least 80% of chronic pelvic pain is associated with endometriosis. 4 – 9  On the other hand, support for a laparoscopic diagnosis comes from data demonstrating that endometriosis can be found in 60% of asymptomatic patients 15  and that progressive disease exists in close to 60% of patients overall. 12  However, the definitive diagnosis of endometriosis is still by laparoscopy.\nDiagnosing endometriosis can sometimes be difficult and is also surgeon-dependent. Surgeons are urged to obtain a confirmed biopsy, and it will often remain unclear whether the implants or adhesions found at surgery are the specific causes of patients' pain. Therefore, even in the presence of endometriosis, suspicion of other causes of chronic pelvic pain is warranted, particularly in patients who do not respond adequately to treatment.\nAlthough laparoscopic excisional surgery offers a better success rate in treating endometriosis, 16 , 17  it also requires a higher level of surgical skills. It is unfortunate that many patients might have inadequate surgical treatment that could lead to persistent and recurrent disease as well as with all of these variables, thus making the diseases difficult to manage. Many patients have gone through numerous laparoscopies and have had a hysterectomy yet still suffer from chronic pelvic pain.\nEndometriosis involvement of the urinary tract has been reported in 16% of women undergoing a laparotomy for endometriosis. 18  Evaluating patients' urinary symptoms is part of the routine in our chronic pelvic pain center. As a result, a cystoscopy was performed on many patients with chronic pelvic pain therefore leading to our findings and conclusion of this study.\nInterstitial cystitis has always been ignored as a major disease that causes chronic pelvic pain. In our study, we have shown through cystoscopy and hydrodistention findings that over 90% of chronic pelvic pain patients have interstitial cystitis. In addition, 80% of CPP patients have biopsy-confirmed endometriosis. Just by simple mathematical calculation, over 70% of chronic pelvic patients suffer from both diseases. If cystoscopy were performed in only 75% of chronic pelvic pain patients based on a positive finding from urinary symptoms, 25% of the interstitial cystitis diagnoses would have been missed. If cystoscopy is only performed later after a negative laparoscopy, not only do you put the patient through 2 separate anesthesia procedures but also a majority of patients (80%) with a diagnosis of interstitial cystitis would have been missed!\nThe results of our study demonstrate the high prevalence and association of the 2 diseases, interstitial cystitis and endometriosis, the evil twins of chronic pelvic pain syndrome. Results of other studies have been similar. 19 ,  20  It is absolutely necessary to perform both endoscopic examinations concurrently with the patient anesthetized in the initial evaluation and treatment of chronic pelvic pain syndrome to avoid unnecessary delay in making the diagnosis of the evil twins because chronic pelvic pain syndrome can be caused by either or both of the evil twins. It is very important to have gynecologists and urologists working together as a team in making an early diagnosis to avoid missing a chance to resolve these 2 chronic debilitating diseases. It may also serve to avoid some unnecessary future surgeries.","source_license":"CC0","license_restricted":false}