{"paper_id":"d932e394-9dc7-4a5c-b6b3-eee78f97cfc5","body_text":"Abstract\nRegulated cell death (RCD) is a fundamental biological process essential for tissue homeostasis and disease regulation. Increasing evidence has demonstrated that RCD plays a pivotal role in the pathogenesis of uterine endometrial diseases, including endometriosis, abnormal decidualization, endometrial receptivity defects, and intrauterine adhesions. However, a comprehensive synthesis centered on the roles of RCD in endometrial diseases is still lacking. This review systematically summarizes the roles of various RCD pathways—apoptosis, autophagy, ferroptosis, pyroptosis, and cuproptosis—in endometrial diseases, emphasizing their interactions with hormonal signaling, molecular mechanisms in different endometrial cells, and cell–cell communication. 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All the authors approved the final manuscript.\nCorresponding authors\nEthics declarations\nConflict of interest\nNone.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nZi, D., Sun, J., Zuo, N. et al. Regulated cell death in endometrial diseases: from molecular mechanisms to targeted therapies. Arch Toxicol 100, 109–125 (2026). https://doi.org/10.1007/s00204-025-04192-z\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00204-025-04192-z","source_license":"CC0","license_restricted":false}