{"paper_id":"d8f59a5a-9f7f-40e7-ab6b-914c855976a7","body_text":"A Hospital-Based Study Assessing the Effect of Intrauterine Instillation of Autologous Platelet Rich Plasma and G-CSF on Endometrial Thickness and Pregnancy Rate in Frozen Embryo Transfer for Women with Thin Endometrium: A Randomized Clinical Study\nAuthors/Creators\n- 1. Senior Resident, Department of Reproductive Medicine, IGIMS, Patna, Bihar, India\n- 2. Professor and HOD, Department of Reproductive Medicine, IGIMS, Patna, Bihar, India\n- 3. Assistant Professor, Department of Reproductive Medicine, IGIMS, Patna, Bihar, India\nDescription\nAbstract\nAim: The aim of the present study was to evaluate the effect of intrauterine instillation of autologous platelet rich\nplasma and G-CSF on endometrial thickness and pregnancy rate in frozen embryo transfer for women with thin\nendometrium.\nMethods: The present retrospective cohort study was conducted in the department of reproductive medicine,\nIGIMS, Patna, Bihar, India. All the patients of age group 22 – 40 years coming to OPD for ART during the period\nof 9 months from March 2022 to November 2022 was selected after randomization into two groups for this study\nafter fulfilling the inclusion & exclusion criteria. Sample sizes of 100 subjects were included in the final analysis.\nResults: The mean age, BMI, S AMH in both the groups were not statistically significant. The most frequent\nfactor for thin endometrium is AKT-or patients on anti-kochs treatment followed by uterine anomalies. The\ndistribution of various other factors have been discussed here like RIF, RPL, endometriosis and ashermanns\nsyndrome which are commonly associated with thin endometrium. Both the groups have similar distribution of\nfactors. The mean of the endometrial thickness before and after are compared in both the groups with injection\nGCSF showing higher increase in endometrial thickness than intrauterine PRP after 48 hours of administration. It\nwas found that for chemical and clinical pregnancy rates, the p values were 0.77 and 0.37 respectively and hence\nstatistically not significant.\nConclusion: Through the analysis done in this study it becomes evidently clear that injection GCSF is superior\nin its action as compared to intrauterine Platelet Rich Plasma in increasing the endometrial thickness in patients\ndiagnosed as thin endometrium for infertility.\nAbstract (English)\nAbstract\nAim: The aim of the present study was to evaluate the effect of intrauterine instillation of autologous platelet rich\nplasma and G-CSF on endometrial thickness and pregnancy rate in frozen embryo transfer for women with thin\nendometrium.\nMethods: The present retrospective cohort study was conducted in the department of reproductive medicine,\nIGIMS, Patna, Bihar, India. All the patients of age group 22 – 40 years coming to OPD for ART during the period\nof 9 months from March 2022 to November 2022 was selected after randomization into two groups for this study\nafter fulfilling the inclusion & exclusion criteria. Sample sizes of 100 subjects were included in the final analysis.\nResults: The mean age, BMI, S AMH in both the groups were not statistically significant. The most frequent\nfactor for thin endometrium is AKT-or patients on anti-kochs treatment followed by uterine anomalies. The\ndistribution of various other factors have been discussed here like RIF, RPL, endometriosis and ashermanns\nsyndrome which are commonly associated with thin endometrium. Both the groups have similar distribution of\nfactors. The mean of the endometrial thickness before and after are compared in both the groups with injection\nGCSF showing higher increase in endometrial thickness than intrauterine PRP after 48 hours of administration. It\nwas found that for chemical and clinical pregnancy rates, the p values were 0.77 and 0.37 respectively and hence\nstatistically not significant.\nConclusion: Through the analysis done in this study it becomes evidently clear that injection GCSF is superior\nin its action as compared to intrauterine Platelet Rich Plasma in increasing the endometrial thickness in patients\ndiagnosed as thin endometrium for infertility.\nFiles\nIJCPR,Vol15,Issue12,Article148.pdf\nFiles\n(354.2 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:a8c012fb71fe1a3fd1dec1f1e8cc22d5\n|\n354.2 kB | Preview Download |\nAdditional details\nDates\n- Accepted\n-\n2023-08-15","source_license":"CC0","license_restricted":false}