{"paper_id":"d6693f34-ac42-4c23-9240-3ed5471ceb13","body_text":"Abstract.\nDanazol, an inhibitor of pituitary gonadotropin with weak androgenic effect, is currently being used for the treatment of endometriosis. In contrast to other C17 alkylated anabolic steroids, it has been rarely associated with the occurrence of primary liver tumors. We present the case of a patient with endometriosis in whom a hepatocellular adenoma was discovered after 14 years of treatment with danazol for endometriosis. The patient showed no clinical signs of a liver tumor and it was only detected by ultrasonography and magnetic resonance imaging (MRI). When long-term danazol therapy is required, regular ultrasonography for monitoring and early tumor detection is recommended.\nAccess this article\nWe’re sorry, something doesn't seem to be working properly.\nPlease try refreshing the page. If that doesn't work, please contact support so we can address the problem.\nSimilar content being viewed by others\nReferences\nBarbieri RL, Ryan KJ (1981) Danazol: endocrine pharmacology and therapeutic applications. Am J Obstet Gynecol 15:453–463\nBaum JK, Bookstein JJ, Holtz F, Klein EW (1973) Possible association between benign hepatomas and oral contraceptives. Lancet 27:926–929\nBoue F, Coffin B, Delfraissy JF (1986) Danazol and cholestatic hepatitis. Ann Intern Med 105:139–140\nBork K, Schneiders V (2002) Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema. J Hepatol 36:707–709\nBork K, Pitton M, Harten P, Koch P (1999) Hepatocellular adenomas in patients taking danazol for hereditary angio-oedema. Lancet 27:1066–1067\nBuamah PK (1985) An apparent Danazol induced primary hepatocellular carcinom: case report. J Surg Oncol 28:114–116\nBühler H, Pirovino M, Akobiantz A, Altorfer J, Weitzel M, Maranta E, Schmid M (1982) Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use. Gastroenterology 82:775–782\nChevalier X, Awada H, Baetz A, Amor B (1990), Danazol induced pancreatitis and hepatitis. Clin Rheumatol 9:239–241\nCrampon D, Barnoud R, Durand M, Ponard D, Jacquot C, Sotto JJ, Letoublon C, Zarski JP (1998) Danazol therapy: an unusual aetiology of hepatocellular carcinoma. J Hepatol 29:1035–1036\nde Menis E, Tramonti P, Conte N (1999) Danazol and multiple hepatic adenomas: peculiar clinical findings in an acromegalic patient. Horm Metab Res 31:476–477\nDmowski WP (1990) Danazol. A sythetic steroid with diverse biologic effects. J Reprod Med 35 [Suppl 1]:69–74\nEdmondson HA, Reynolds TB, Henderson B, Benton B (1977) Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 86:180–182\nel-Roeiy A, Dmowski WP, Gleicher N, Radwanska E, Harlow L, Binor Z, Tummon I, Rawlins RG (1988) Danazol but not gonadotrophin releasing hormone agonists suppresses auto antibodies in endometriosis. Fertil Steril 50:864–871\nFremand JP, Levy Y, Bouscary D, D'Agay MF, Clot P, Frija J, Brouet JC (1990) Danazol-induced hepatocellular adenoma. Am J Med 88:529–530\nIshak KG (1988) Benign tumors and pseudotumors of the liver. Appl Pathol 6:82–104\nIshak KG, Zimmerman HJ (1987) Hepatotoxic effects of the anabolic/androgenic steroids. Sem Liver Dis 7:230–236\nIshak KG, Zachary DG, Stocker JT (2001) Benign hepatocellular tumors. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology, third series. Armed Forces Institute of Pathology, Waschington DC, pp 9–48\nKahn H, Manzarbeitia C, Theise N, Schwartz M, Miller C, Thing SN (1991) Danazol induced hepatocellular adenomas. A case report and review of literature. Arch Pathol Lab Med 115:1054–1057\nMakdisi WJ, Cherian R, Vanveldhuizen PJ, Talley RL, Stark SP, Dixon AY (1995) Fatal peliosis on the liver and spleen in a patient with agnogenic myeloid metaplasia treated with danazol. Am J Gastroenterol 90:317–318\nMathieu D, Kobeiter H, Maison P, Rahmouni A, Cherqui D, Zafrani ES, Dhumeaux D (2000) Oral contraceptive use and focal nodular hyperplasia of the liver. Gastroenterology. 118:560–564\nMiddleton C, McCaughan GW, Painter DM., Stephen MS, Beale M, Fraser I (1989) Danazol and hepatic neoplasia: a case report. Aust NZ J Med 19:733–734\nNesher G, Dollberg L, Zimran A, Hershko C (1985) Hepatosplenic peliosis after danazol and glucocorticoids for ITP. N Engl J Med 24:242–243\nOberti F, Drouet D'Aubigny N, Farges O, Cales P (1994) Adenome haptocellulaire chez une femme après prise de danazol. Gastoenterol Clin Biol. 18:902–903\nPearson K, Zimmerman HJ (1980) Danazol and liver damage. Lancet 22:645–646\nRooks JB, Ory HW, Ishak KG, Strauss LT, Greenspan JR, Hill AP, Tyler CW Jr (1979) The Cooperative Liver Tumor Study Group: epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 242:644–648\nVeit V, Hardwisgen J, Bernit E, Gachon J, Kaplanski G, Schlienger JL (1999) Traintment par danazol, une étiologie exceptionelle d'hépatocarcinome: à prospos d'une observation. Rev Méd Intern 20:6346\nVincens M, Athea N, Dougados M, Jungers P (1984) Increase in transaminase levels during treatment with danazol in lupus patients. Therapie 39:541–544\nWeill BJ, Menkes CJ, Cormier C, Louvel A, Dougados M, Houssin D (1988) Hepatocellular carcinoma after danazol therapy. J Rheumatol 15:1447–49\nZurlo JJ, Frank MM (1990) The long-term safety of danazol in women with hereditary angioedema. Fertil Steril 54:64–72\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nBartley, J., Loddenkemper, C., Lange, J. et al. Hepatocellular adenoma and focal nodular hyperplasia after long-term use of danazol for endometriosis: a case report. Arch Gynecol Obstet 269, 290–293 (2004). https://doi.org/10.1007/s00404-002-0435-z\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-002-0435-z","source_license":"CC0","license_restricted":false}