{"paper_id":"d4cb9688-1434-4907-a87b-1d0d5dc935ef","body_text":"Abstract\nEndometriosis is a benign gynecologic disorder. It is particularly common among young women and may make pregnancy difficult. In this study molecular level characterization of endometriosis tissues were performed using Raman spectroscopy in combination with multivariate statistical analysis. Three hundred sixty six Raman spectra recorded from different points of seventy two tissue samples, taken from the cyst walls of twelve patients were examined. Principle component analysis (PCA) followed by linear discriminant analysis (LDA) were performed on the Raman data, and the samples were then classified into three groups: severe, moderate, and weak endometriosis. In the severe endometriosis group, the relative band intensities of DNA were increased. Moreover, increase in pyrrole moieties and kynurenine were seen. 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Kuromaki, E. Morioka, K. Arisawa, and T. Terao, Int. J. Gynecol. Cancer 17, 37 (2007).\nFunding\nThis study was supported by the Research funds of Istanbul University [ONAP-2423, BYP-2018-30589, BYP-2018-30928, BYP-2018-29289, BYP-2018-30236].\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nCOMPLIANCE WITH ETHICAL STANDARDS\nAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.\nCONFLICT OF INTEREST\nThe authors declare that they have no conflicts of interest.\nRights and permissions\nAbout this article\nCite this article\nAkyuz, S., Celik, S., Usta, A.T. et al. Using Raman Spectroscopy to Investigate the Molecular Level Characteristics of Endometriosis. Opt. Spectrosc. 128, 1318–1327 (2020). https://doi.org/10.1134/S0030400X20080044\nReceived:\nRevised:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1134/S0030400X20080044","source_license":"CC0","license_restricted":false}