{"paper_id":"d373956c-6949-41df-9707-0818099d2fa0","body_text":"Metabiose project: an endometriosis predictive signature through metabolomics \nEndometriosis is a common chronic disease characterized by growth and proliferation of endometrial \ntissue outside the uterus. It affects 10% of woman in their reproductive years and its \npathophysiology is still not completely known. The non-specific symptoms and the lack of non-\ninvasive diagnostic contribute to diagnostic delays of an average of 7.5 years. In fact, the actual gold-\nstandard represented by laparoscopy, is an invasive procedure that results inappropriate for periodic \nrestaging of endometriosis after treatment.  \nIn this context, through the use of an NMR-based metabolomics approach, we aim to identify a panel \nof biomarkers that could be linked to the pathology. In this study, the urine metabolome obtained \nfrom samples of 122 women affected by endometriosis was compared to the one of healthy woman; \na combination of biomarkers and clinical measures linked to the disease was identified and validated \non a new small cohort. The encouraging results show how metabolomics represents a powerful and \npromising tool for personalized medicine approach in disease like endometriosis.  \n \n \nArianna Cirillo ¹, Justine Leenders ¹, Marlyne Squatrito ², Céline Bugli ³, Bernadette Govaerts ⁴, \nMichèle Nisolle ⁵, Carine Munaut ², Pascal de Tullio ¹ \n \n1. Center for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of \nLiège, B-4000 Liège, Belgium \n2.  Laboratory of Tumor and Development Biology, University of Liège, Sart Tilman, B-4000 Liège, \nBelgium \n3. Plateforme technologique de Support en Méthodologie et Calcul Statistique, Université \nCatholique de Louvain, Louvain-La-Neuve, Belgium \n4. Institute of Statistics, Biostatistics and Actuarial Sciences, Université Catholique de Louvain, Voie \ndu Roman Pays 20, 1348 Louvain-La-Neuve, Belgium \n5. Department of Gynecology, Catholic University of Louvain, Cliniques Universitaires St-Luc, \nBrussels, Belgium","source_license":"CC0","license_restricted":false}