{"paper_id":"d1b80aca-44fb-4dc9-a96d-62750b6f6528","body_text":"Vascular involvement in endometriosis and adenomyosis (reply to letter to the editor)\nAffiliations & Notes\nDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143\nArticle Info\nPublication History:\nPublished online December 18, 2025\nFootnotes:\nThe authors report no conflict of interest.\nThis study was supported by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant number: P01 HD 106414).\nDOI: 10.1016/j.ajog.2025.12.047 External LinkAlso available on ScienceDirect External Link\nCopyright: © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.\nLinked Articles\n- Vascular involvement in endometriosis and adenomyosisAmerican Journal of Obstetrics & GynecologyVol. 234Issue 6December 18, 2025\nDownload started\nOkThe authors would like to thank Drs Gupta and Pai for their letter to the editors related to our recent article.1,2 In our review, we focused first on clinical characteristics shared and discordant between endometriosis and adenomyosis—“sister disorders of the endometrium but not identical twins.” Next, we reviewed the most recent literature on the eutopic endometrium and the ectopic endometrium at single-cell resolution in these disorders that have provided huge insights into the major cell types and subtypes, activation states, and progenitors in these tissues, signaling pathways, cell-cell communications, trajectories of cell transdifferentiation, and opportunities for novel drug discovery and challenges that accompany this type of research.\nReferences\n1.\nGupta, S. ∙ Pai, S.A.\nVascular involvement in endometriosis and adenomyosis\nAm J Obstet Gynecol. 2026; 234:e240\n2.\nGiudice, L.C. ∙ Liu, B. ∙ Irwin, J.C.\nEndometriosis and adenomyosis unveiled through single-cell glasses\nAm J Obstet Gynecol. 2025; 232:S105-S123\n3.\nSampson, J.A.\nMetastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation\nAm J Pathol. 1927; 3:93-110.43\n4.\nFitzpatrick, M.B. ∙ Hammer, P.M. ∙ Yang, E.J. ...\nIntravascular adenomyomatosis: a morphologic variant of intravenous leiomyomatosis associated with endometriosis and potential for misdiagnosis\nHum Pathol. 2022; 120:18-25\n5.\nHabiba, M. ∙ Ruscito, I. ∙ Bianchi, P. ...\nIs adenomyosis associated with systemic vascular complications?\nReprod Med. 2025; 6:38","source_license":"public-domain-us","license_restricted":false}