{"paper_id":"ca856bad-a667-4a32-8874-c87237cf263c","body_text":"Abstract\nBiomarkers relevant to women’s health have not been investigated as widely as in some other therapeutic areas. Those relevant to cancer of breast and ovaries are discussed in the chapter on cancer biomarkers. This section will deal with biomarkers of menopause, endometriosis and disorders associated with pregnancy.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nAdachi J, Kumar C, Zhang Y, et al. The human urinary proteome contains more than 1500 proteins including a large proportion of membranes proteins. Genome Biol. 2006;7:R80.\nAjayi F, Kongoasa N, Gaffey T, et al. Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. Am J Obstet Gynecol. 2008;199:557.e1–557.e10.\nAustdal M, Tangerås LH, Skråstad RB, et al. First trimester urine and serum metabolomics for prediction of preeclampsia and gestational hypertension: a prospective screening study. Int J Mol Sci. 2015;16:21520–38.\nBradford C, Severinsen R, Pugmire T, et al. Analytical validation of protein biomarkers for risk of spontaneous preterm birth. Clin Mass Spectrom. 2017;3:25–38.\nBramham K, Seed PT, Lightstone L, et al. Diagnostic and predictive biomarkers for pre-eclampsia in patients with established hypertension and chronic kidney disease. Kidney Int. 2016;89:874–85.\nCantonwine DE, Zhang Z, Rosenblatt K, et al. Evaluation of proteomic biomarkers associated with circulating microparticles as an effective means to stratify the risk of spontaneous preterm birth. Am J Obstet Gynecol. 2016;214:631.e1–631.e11.\nDiaz SO, Pinto J, Graça G, et al. Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma. J Proteome Res. 2011;10:3732–42.\nFlores I, Rivera E, Mousses S, et al. Identification of molecular markers for endometriosis in blood lymphocytes by using deoxyribonucleic acid microarrays. Fertil Steril. 2006;85:1676–83.\nGormley M, Ona K, Kapidzic M, et al. Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations. Am J Obstet Gynecol. 2017;pii:S0002-9378(17)30441–6.\nLambalk CB, van Disseldorp J, de Koning CH, Broekmans FJ. Testing ovarian reserve to predict age at menopause. Maturitas. 2009;63:280–91.\nMaron JL, Johnson KL, Slonim D, et al. Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. Clin Invest. 2007;117:3007–19.\nNorwitz ER, Tsen LC, Park JS, et al. Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia. Am J Obstet Gynecol. 2005;193:957–64.\nOthman E-D, Hornung D, Salem HT, et al. Serum cytokines as biomarkers for nonsurgical prediction of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2008;137:240–6.\nRamiro-Cortijo D, Herrera T, Rodríguez-Rodríguez P, et al. Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications. Placenta. 2016;47:37–45.\nSaarela T, Hiltunen M, Helisalmi S, et al. Adiponectin gene haplotype is associated with preeclampsia. Genet Test. 2006;10:35–9.\nSahore V, Kumar S, Rogers CI, et al. Pressure-actuated microfluidic devices for electrophoretic separation of pre-term birth biomarkers. Anal Bioanal Chem. 2016;408:599–607.\nSowers MR, Eyvazzadeh AD, McConnell D, et al. Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition. J Clin Endocrinol Metab. 2008;93:3478–83.\nvan den Berg CB, Duvekot JJ, Güzel C, et al. Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women. Proteomics Clin Appl. 2017;11(1–2) doi:10.1002/prca.201600082.\nvan Dijk M, Oudejans CB. STOX1: key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation. J Pregnancy. 2011;2011:521826.\nVisca E, Lapaire O, Hösli I, Hahn S. Cell-free fetal nucleic acids as prenatal biomarkers. Expert Opin Med Diagn. 2011;5:151–60.\nWang T, Zhou R, Gao L, et al. Elevation of urinary adipsin in preeclampsia: correlation with urine protein concentration and the potential use for a rapid diagnostic test. Hypertension. 2014;64:846–51.\nWeel IC, Baergen RN, Romão-Veiga M, et al. Association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia. PLoS One. 2016;11(6):e0157584.\nAuthor information\nAuthors and Affiliations\nRights and permissions\nCopyright information\n© 2017 Springer Science+Business Media LLC\nAbout this chapter\nCite this chapter\nJain, K.K. (2017). Biomarkers in Gynecology and Obstetrics. In: The Handbook of Biomarkers. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7431-3_17\nDownload citation\nDOI: https://doi.org/10.1007/978-1-4939-7431-3_17\nPublished:\nPublisher Name: Humana Press, New York, NY\nPrint ISBN: 978-1-4939-7430-6\nOnline ISBN: 978-1-4939-7431-3\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)","source_license":"CC0","license_restricted":false}