{"paper_id":"ca5d15de-1566-47c5-9a9f-8e93778481c3","body_text":"Abstract\nGestrinone (R2323) is a trienic steroid with an ethyl group in position 13, close to norgestrienone which has a methyl group in the same position, and which is marketed in France as a contraceptive pill in association with ethinyl oestradiol (Figure 1). The compound shows an antioestrogenic activity, and a true antiprogesterone activity by competitive binding to the progesterone receptors1,2.\nPreview\nUnable to display preview. Download preview PDF.\nSimilar content being viewed by others\nReferences\nAzadian-Boulanger, G., Secchi, J. and Sakiz, E. (1971). Biological study of the anti-progesterone effect of R2323. In Proceedings of the 7th World Congress of Fertility and Sterility. p. 129. ( Amsterdam: Excepta Medica )\nSakiz, E. and Azadian-Boulanger, G. (1970). R2323. An original contraceptive compound. In Proceedings of the Third International Congress on Hormonal Steroids. p. 865. (Amsterdam: Excerpta Medica )\nCoutinho, E. M. (1982). Treatment of endometriosis with gestrinone (R2323), a synthetic anti-estrogen, antiprogesterone. Am. J. Obstet. Gynecol., 144, 895\nAmerican Fertility Society (1979). Classification of endometriosis. Fertil. Steril., 32, 633\nDmowski, W. P. and Cohen, M. R. (1978). Antigonadotropin (danazol) in the treatment of endometriosis. Am. J. Obstet. Gynecol., 130, 41\nMora, G., Faundes, A. and Pastore, U. (1974). Clinical evaluation of an oral progestin contraceptive, R2323, 5mg, administered at weekly intervals. Contraception, 10, 145\nVictor, A. and Johansson, E. D. B. (1975). The effect of weekly administration of an oral progestogen - R2323 - on the ovarian function. Contraception, 12, 89\nSpellacy, W.N., Mahan, C. S., Buhi, W.C., Dumbaugh, V.A. and Birk, S.A. (1978). Blood glucose, insulin, cholesterol and triglyceride levels in women treated for six months with the weekly oral contraceptive R2323. Contraception, 18, 121\nAudebert, A. J. M., Bernard, I. and Emperaire, J. C. (1977). Treatment of endometriosis with danazol. Gynécologie, 1, 29\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 1984 MTP Press Limited\nAbout this chapter\nCite this chapter\nEmperaire, J.C., Audebert, A.J.M. (1984). Objective assessment of medical treatment of endometriosis with gestrinone (R2323). In: Harrison, R.F., Bonnar, J., Thompson, W. (eds) Diagnosis and Management of Tubo-Uterine Factors in Infertility. Studies in Fertility and Sterility, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7621-7_22\nDownload citation\nDOI: https://doi.org/10.1007/978-94-011-7621-7_22\nPublisher Name: Springer, Dordrecht\nPrint ISBN: 978-94-011-7623-1\nOnline ISBN: 978-94-011-7621-7\neBook Packages: Springer Book Archive\nKeywords\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}