{"paper_id":"ca24d609-71db-42fe-b4df-6c041c3a6001","body_text":"Noninvasive diagnosis of external genital endometriosis based on the determination of cytokines controlling angiogenesis\n- Authors: Suleimanova S.T.1, Yarmolinskaya M.I.1, Selkov S.A.1, Sokolov D.I.1\n-\nAffiliations:\n- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\n- Issue: Vol 26, No 1 (2026)\n- Pages: 14-30\n- Section: Reviews\n- Published: 30.03.2026\n- URL: https://journals.eco-vector.com/MAJ/article/view/642079\n- DOI: https://doi.org/10.17816/MAJ642079\n- EDN: https://elibrary.ru/GVUEHL\n- ID: 642079\nCite item\nAbstract\nExternal genital endometriosis is a chronic inflammatory disease affecting 10% of women of reproductive age, characterized by neoangiogenesis in endometriotic implants, which is controlled by a variety of factors. Recently, a great deal of research has been devoted to studying the pathogenetic role of cytokines and other factors in peripheral blood and peritoneal fluid in endometriosis. Nevertheless, a highly sensitive and highly specific marker for the noninvasive diagnosis of external genital endometriosis has not yet been identified. Color Doppler imaging, being one of the noninvasive methods for studying the vascular bed, is increasingly used to determine the type of vascularization in malignant tumors. Although endometriosis is considered a benign lesion, it still has signs of invasiveness and distant metastasis, with similar patterns of formation of the vascular bed feeding endometriotic implants. The purpose of this review was to synthesize published data on the content and pathogenetic role of cytokines and factors controlling angiogenesis in peritoneal fluid and peripheral blood in women with endometriosis, and also to correlate these data with color Doppler imaging parameters in external genital endometriosis.\nFull Text\nAbout the authors\nSharifat T. Suleimanova\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nAuthor for correspondence.\nEmail: sharifat_abdulaeva@mail.ru\nORCID iD: 0009-0005-5778-3311\nRussian Federation, Saint Petersburg\nMaria I. Yarmolinskaya\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: m.yarmolinslaya@gmail.com\nORCID iD: 0000-0002-6551-4147\nSPIN-code: 3686-3605\nMD, Dr. Sci. (Medicine), Professor, Professor of the Russian Academy of Sciences, Honored Scientist of the Russian Federation\nRussian Federation, Saint PetersburgSergey A. Selkov\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: selkov@mail.ru\nORCID iD: 0000-0003-1560-7529\nSPIN-code: 7665-0594\nMD, Dr. Sci. (Medicine), Professor, Honored Scientist of the Russian Federation\nRussian Federation, Saint PetersburgDmitriy I. Sokolov\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: falcojugger@yandex.ru\nORCID iD: 0000-0002-5749-2531\nSPIN-code: 3746-0000\nCand. Sci. (Biology), Assistant Professor\nRussian Federation, Saint PetersburgReferences\n- Moazen S, Arjmand MH. The role of local angiotensin II/angiotensin type 1 receptor in endometriosis: a potential target for new treatment approaches. Curr Mol Pharmacol. 2024;17:e18761429315431. doi: 10.2174/0118761429315431240712100124 EDN: EDFQQV\n- Oală IE, Mitranovici M-I, Chiorean DM, et al. 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