{"paper_id":"c2f36fea-f958-4cad-89b5-da4ce835ca02","body_text":"Spindle cell variant of leiomyoma exhibiting myxoid change and calcification: a rare case report\nDOI:\nhttps://doi.org/10.18203/2320-1770.ijrcog20253917Keywords:\nLeiomyoma, Endometrial cancer, Myxoid degeneration, Spindle cellAbstract\nUterine leiomyomas, commonly referred to as fibroids, are the most prevalent benign tumors found in women of reproductive age, characterised by the proliferation of smooth muscle cells within the uterus. While the vast majority of leiomyomas are benign, a small percentage (approximately 1%) can undergo malignant transformation into leiomyosarcoma, complicating management and prognosis. Here we report a case of 51-year-old P1L1 presented to the outpatient department (OPD) with complaints of heavy menstrual bleeding for two years. Patient was examined and investigated. On clinical examination, a palpable pelvic mass of approximately 20×15 cm noted measuring about 24 weeks in size. On radiological examination, revealed a heterogeneously hyperechoic solid-cystic lesion measuring 12.5×10.5×7.6 cm with features suggestive of endometrial carcinoma. Total abdominal hysterectomy with bilateral salpingo - oophorectomy. Histopathological examination (HPE) report revealed endometrial hyperplasia without atypia. The myometrium reveals features of adenomyosis and leiomyoma. The subserosal fibroid consists of spindle cells in interlacing fascicles, with areas of calcification and focal myxoid change.\nMetrics\nReferences\nYang Q, Madueke-Laveaux OS, Cun H, Wlodarczyk M, Garcia N, Carvalho KC, et al. Comprehensive review of uterine leiomyosarcoma: pathogenesis, diagnosis, prognosis, and targeted therapy. Cells. 2024;13:1106. DOI: https://doi.org/10.3390/cells13131106\nPanda A, Mahoorkar DN, Reddy N, Reddy BM. Myxoid degeneration of leiomyoma-a masquerade. Int J Reprod Contracept Obstet Gynecol. 2022;11:3415-7. DOI: https://doi.org/10.18203/2320-1770.ijrcog20223145\nKawakami S, Togashi K, Konishi I. Red degeneration of uterine leiomyoma: MR appearance. J Comput Assist Tomogr. 1994;18(6):925-8. DOI: https://doi.org/10.1097/00004728-199411000-00014\nCruz M, Murakami T, Suda T. Myxoid leimyoma of the uterus: CT and MRI features. Abdomin Imaging. 2001;26:98-100. DOI: https://doi.org/10.1007/s002610000102\nKaushik C, Prasad A, Singh Y, Baruah BP. Case series- Cystic degeneration in Uterine leiomyomas. Indian J Radiol Imaging. 2008;18(1):69-72. DOI: https://doi.org/10.4103/0971-3026.35820\nRupa P, Meena Thapa. Case Report- A case report on an unusual degeneration of uterine leiomyoma: Myxoid degeneration. J Kathmandu Med Coll. 2018;7. DOI: https://doi.org/10.3126/jkmc.v7i4.23325\nChaouki M, Marouen N, Najet BM. An unusual presentation of uterine leiomyoma: Myxoid leiomyoma. Int J Case Rep Images. 2012;3(3):1-3. DOI: https://doi.org/10.5348/ijcri-2012-03-96-CR-1\nMonika A, Kajal S. A perplexing case of Cellular Leiomyoma with excessive Myxoid Degeneration. J Clin Diagnost Res. 2018;12(7):QD03-5.\nKamra HT, Dantkale SS, Birla K. Myxoid Leiomyoma of cervix. J Clin Diagnost Res. 2013;7(12):2956-7. DOI: https://doi.org/10.7860/JCDR/2013/6171.3805","source_license":"CC0","license_restricted":false}