{"paper_id":"c218f746-361f-45f9-aee8-896ada11c75c","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 17-23|Published online on: January 1, 2010https://doi.org/10.3892/ijmm_00000308\n- Expand metrics +\nWe previously reported that activin A, not inhibin, was localized to endometrial tissues, and that the endometrium might be a major source of activin A during the menstrual cycle, using an immunohistochemical method. However, there are few detailed reports concerning the expression of inhibin subunits, activin receptors and Smad proteins in the ectopic endometrial tissues of endometriosis. In this study, our purpose was to evaluate the immunohistochemical localization of inhibin α-, βA-subunits, activin A, activin receptor, and Smad proteins in ovarian endometriosis. Tissue samples from ovarian endometriosis were obtained from 13 women. Normal endometrial tissues were obtained during the proliferative phase from 5 premenopausal women without endometriosis who were undergoing a hysterectomy for the treatment of uterine cervical intraepithelial neoplasia 3. We examined the immunohistochemical localization of inhibin/activin α-, βA-subunit, activin A, activin receptors types IA, IB, IIA, IIB, Smad2, Smad3 and Smad4 using an avidin-biotin-peroxidase complex technique. No immunostaining for the α-subunit of inhibin was observed in ovarian endometriosis and the normal endometrium. Positive immunostaining for the βA-subunit of inhibin, activin A, activin receptors types IA, IB, IIA, IIB, Smad2, Smad3 and Smad4 was observed in ovarian endometriosis and the normal endometrium. In conclusion, these results suggest that activin A, but not inhibins, is produced by ovarian endometriosis and the normal endometrium, and that the activin signal transduction system exists in both ovarian endometriosis and the normal endometrium.\nCopy and paste a formatted citation\nSpandidos Publications style\nMabuchi Y, Yamoto M, Minami S and Umesaki N: Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis. Int J Mol Med 25: 17-23, 2010.\nAPA\nMabuchi, Y., Yamoto, M., Minami, S., & Umesaki, N. (2010). Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis. International Journal of Molecular Medicine, 25, 17-23. https://doi.org/10.3892/ijmm_00000308\nMLA\nMabuchi, Y., Yamoto, M., Minami, S., Umesaki, N.\"Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis\". International Journal of Molecular Medicine 25.1 (2010): 17-23.\nChicago\nMabuchi, Y., Yamoto, M., Minami, S., Umesaki, N.\"Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis\". International Journal of Molecular Medicine 25, no. 1 (2010): 17-23. https://doi.org/10.3892/ijmm_00000308","source_license":"CC0","license_restricted":false}