{"paper_id":"c1cbe5e1-491c-4459-8a5d-b69bd61997d5","body_text":"The effects of levonorgestrel intra-uterine system on adenomyosis and endometriosis: A three year follow up study\nResearch Article\nAbstract\nObjective: To study effects of levonorgestrel intra-uterine system (LNG-IUS) on adenomyosis with and without endometriosis.\nDesign: Fifty-eight women with a confirmed diagnosis of adenomyosis after exclusion of confounding factors, and detection or exclusion of endometriosis were selected. They were categorized into group A (only adenomyosis, n=44) and group B (adenomyosis plus endometriosis, pre-treated by laparoscopic surgery, n=14) received LNG-IUS between July 2004 and January 2006 and were followed up on five different parameters.\nResults: Analysis of three years’ follow up shows mean reduction of different variables in groups A and B as dysmenorrhoea (visual analogue scale) 98.2±3.9% and 98.3±3.7% (p<0.0001) menstrual bleeding (blood-loss assessment chart) 92.2±11.2% and 85.0±17.5% (p<0.0001), chronic pelvic pain (pain-calendar) 98.8±2.7% and 96.4±4.9% (p<0.0001); uterine volume 27.8±9.0% and 28.7±9.6% (p<0.0005) maximum endo-myometrial junctional-zone thickness 30.2±7.9% and 26.0±4.8% (p<0.0005). Effects on groups A and B were comparable. Other observations were – amenorrhoea-27.5%, intermenstrual bleeding-37.3% and expulsion-6.9%.\nConclusion: LNG-IUS is equally effective for long-term conservative management of both adenomyosis alone and with co-existent endometriosis.\nKey words: Adenomyosis; endometriosis; conservative treatment; LNG-IUS.\nDOI: http://dx.doi.org/10.4038/sljog.v32i2.3976\nSLJOG 2010; 32(2): 27-33","source_license":"CC0","license_restricted":false}