{"paper_id":"c0af327f-f5a2-4a5a-820a-9fd42aed773c","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 423-429|Published online on: April 1, 2001https://doi.org/10.3892/ijmm.7.4.423\n- Expand metrics +\nIncreased concentrations of TGF-β1 in endometriotic tissue are considered important in the pathophysiology of endometrial diseases since TGF-β1 may inhibit natural killer activity and induce angiogenesis and proliferation of endometrial stromal cells. In the present study we report on TGF-β1, IGF-1 and their receptor localization, as detected by Northern hybridization and immunohistochemistry, in ovarian endometriotic tissues removed during surgical procedures. We detected comparable expression of IGF-1 and IGF-1 receptor in the stromal and epithelial compartments, thus confirming disregulated expression of the IGF system in ovarian endometriosis. On the contrary, strongly increased TGF-β1 steady state level mRNA expression was detected in all endometriotic samples. In addition, we demonstrated weak TGF-β1 immunohistochemical expression in the epithelial lining and intense expression in the cellular stroma of ovarian endometriomas, thus suggesting that TGF-β1 could have an important role in the maintenance and propagation of the disease. On the basis of these preliminary results we can assume that TGF-β1, IGF-1 and their receptors may play an important role in the pathogenesis of endometriosis.\nCopy and paste a formatted citation\nSpandidos Publications style\nLoverro G, Maiorano E, Napoli A, Selvaggi L, Marra E and Perlino E: Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study. Int J Mol Med 7: 423-429, 2001.\nAPA\nLoverro, G., Maiorano, E., Napoli, A., Selvaggi, L., Marra, E., & Perlino, E. (2001). Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study. International Journal of Molecular Medicine, 7, 423-429. https://doi.org/10.3892/ijmm.7.4.423\nMLA\nLoverro, G., Maiorano, E., Napoli, A., Selvaggi, L., Marra, E., Perlino, E.\"Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study\". International Journal of Molecular Medicine 7.4 (2001): 423-429.\nChicago\nLoverro, G., Maiorano, E., Napoli, A., Selvaggi, L., Marra, E., Perlino, E.\"Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study\". International Journal of Molecular Medicine 7, no. 4 (2001): 423-429. https://doi.org/10.3892/ijmm.7.4.423","source_license":"CC0","license_restricted":false}