{"paper_id":"c07797c8-6f25-4801-bc39-c473d65c4410","body_text":"Abstract\nIntroduction\nEndometriosis is a chronic inflammatory condition. Interleukin (IL) 37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study investigated the gene and protein expression of IL-37 in the eutopic and ectopic endometrium of women with ovarian endometriosis and in the endometrium of patients without endometriosis.\nMethods\nEutopic and ectopic endometria (n = 24) were collected from patients with ovarian endometriosis, and control endometria (n = 15) were obtained from women without endometriosis. Quantitative real-time polymerase chain reaction was used to measure the gene expression levels of IL-37, and immunohistochemistry was performed to assess the protein expression levels of IL-37.\nResults\nThe gene and protein expression levels of IL-37 in both eutopic and ectopic endometrium of women with ovarian endometriosis were significantly higher than in the endometrium of patients without endometriosis. Compared to the eutopic endometrium of patients with ovarian endometriosis, IL-37 gene and protein expression levels were significantly higher in the ectopic endometrium.\nConclusion\nThese findings suggest that increased expression of IL-37 was present in eutopic and ectopic endometrium of women with ovarian endometriosis, which might be involved in the inflammatory process of endometriomas.\nReferences\nGiudice LC.Clinical practice. Endometriosis. The New England Journal of Medicine. 2010;362(25):2389–2398.\nde Ziegler D, Borghese B, Chapron C. 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Sci. 23, 244–248 (2016). https://doi.org/10.1177/1933719115602775\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719115602775","source_license":"CC0","license_restricted":false}