{"paper_id":"bda02f23-ec85-42bd-81cb-5955e7deacb0","body_text":"Pengaruh Pemberian Ekstrak Meniran Terhadap Ekspresi MMP 9 Dan Luas Lesi Endometriosis Pada Mencit Model Endometriosis\nDownloads\nAbstrak\nPada endometriosis, ekspresi MMP 9 ditemukan dalam konsentrasi yang lebih tinggi.Sekresi MMP 9 disebabkan oleh aktivasi ROS di rongga peritoneum dan menyebabkan peningkatan stres oksidatif. Peningkatan aktivitas MMP 9 pada endometriosis dapat memfasilitasi invasi yang mengakibatkan pembentukan lesi endometriosis. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak meniran (Phyllanthus niruri L.) pada dosis 14,28 dan 56 mg / 20 gBB terhadap ekspresi MMP 9 dan luas lesi endometriosis pada mencit model endometriosis. Penelitian ini merupakan penelitian eksperimental laboratorium. Dua puluh empat tikus betina digunakan sebagai sampel dan dibagi menjadi 4 kelompok: 1 kelompok kontrol dan 3 kelompok perlakuan. Keduanya, kelompok kontrol dan kelompok perlakuan diinduksi dan dijadikan model endometriosis selama 14 hari. 14 hari berikutnya, Na-CMC 0,5% diberikan kepada kelompok kontrol, sedangkan ekstrak Phyllanthus niruri L. pada dosis 14, 28 dan 56 mg / 20 gBB diberikan kepada kelompok perlakuan secara oral. Luas lesi endometriosis pada rongga peritoneum diperiksa. Hasil penelitian ini menunjukkan bahwa ada perbedaan yang signifikan pada ekspresi MMP 9 dengan rata-rata (± SD) K1, K2, K3, K4 sebesar 2.19±1.77, 0.19±0.13, 0.14±0.13, 0.08±0.14 dan luas lesi endometriosis pada K1, K2, K3, K4 adalah 120.04±100.09, 73.86±36.72, 69.08±15.73, 25.53±3.51. Kesimpulannya, ekspresi MMP 9 dan lesi endometriosis secara signifikan lebih rendah pada kelompok yang diobati dengan ekstrak Phyllanthus niruri L. herbal.\nKata kunci : ekstrak meniran, endometriosis, ekspresi MMP 9, luas lesi endometriosis\nDAFTAR PUSTAKA\nArumugam K and Dip YC. 1995. 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Majalah Obstetri dan Ginekologi, 10(1): 43-50.\nCopyright and Licensed\nAuthors who publish with this journal agree to the following terms:\n- The copyright of the submitted manuscript is transfrred to the Journal Biosains Pascasarjana. The corresponding author on behalf of all authors signs the copyright transfer agreement form along with the authors declaration that can be found here.\n- The formal legal aspect of journal publication refers to the Creative Commons Attribution-Share Alike (CC BY-SA) license.\n- Every publication (print/electronic) is open access for educational, research, and library purposes. In addition to the objectives mentioned above, the editorial board is not responsible for copyright infringement.","source_license":"CC0","license_restricted":false}