{"paper_id":"bd8b918d-6132-4f17-b81f-2ee8e0bcd545","body_text":"Abstract\nBackground: Endometriosis commonly presents with dysmenorrhea, non-menstrual pelvic pain, and infertility. Elagolix is an oral, short-acting, gonadotropin-releasing hormone antagonist acting through complete estrogen suppression.\nObjective: To evaluate the evidence from published randomized controlled trials (RCTs) about the efficacy and safety of Elagolix in the treatment of endometriosis associated pain.\nSearch strategy: Electronic databases containing articles published between January 2000 and February 2020 were searched using the MeSH terms (Elagolix OR gonadotropin-releasing hormone antagonist OR GnRH antagonist OR antigonadotropin) AND (endometriosis) AND (pelvic pain).\nSelection criteria: All RCTs assessing the efficacy of Elagolix in the treatment of pain associated with endometriosis were considered for this network meta-analysis, where five studies were deemed eligible for this review.\nData collection and analysis: The mean difference (MD) and confidence intervals (95% CI) for continuous outcomes including analgesic use, dysmenorrhea, non-menstrual pelvic pain, and quality of life were calculated.\nMain results: Elagolix 250 mg reduced dysmenorrhea significantly, as compared to placebo, (MD = -0.41, 95% CI [-0.7, -0.13]) at 12 weeks, while Elagolix 200 mg reduced dysmenorrhea significantly (MD= -1.2, 95% CI [-1.9, -0.57]) compared to placebo after 24 weeks of treatment.\nConclusions: Elagolix 200 mg seems to be an effective drug with fewer side effects when used to reduce dysmenorrhea and non-menstrual pelvic pain after 24 weeks of treatment in patients with endometriosis.\nKeywords: Endometriosis, Elagolix, GnRH antagonist, pain, dysmenorrhea\nHow to Cite:\nMattar, O. M., Namous, L. O., Ros, M., Fathi, M., Elgendy, F. A., Elghazaly, S. M., Ibrahim, A. H., Gadallah, A., Faraag, E. A., Sayed, O., Samy, A. & Abbas, A. M., (2021) “Efficacy and safety of Elagolix in the treatment of endometriosis associated pain: a systematic review and network meta-analysis”, Proceedings in Obstetrics and Gynecology archive 10(2), 1–13. doi: https://doi.org/10.17077/2154-4751.1510\nRights: Copyright © 2021 the authors\nDownloads:\nDownload pdf\nView PDF\n2852 Views\n239 Downloads","source_license":"CC0","license_restricted":false}