{"paper_id":"bc69a90e-6abe-426f-b739-692b5dd48953","body_text":"conferenceseries.com\nVolume: 00Gynecology & Obstetrics\nPage 9\nReproduction Fertility 2021\nJuly 21, 2021 | Webinar\nJuly 21, 2021 | Webinar\n3rd International Conference on Womens  HealtH , RepR oduction  and  FeRtility\nMariana Robalo Cordeiro et al., Gynecol Obstet (Sunnyvale) 2021, ISSN: 2161-0932\nEndometriosis: Unlocking age boundaries\nMariana Robalo Cordeiro1, Bárbara Laranjeiro1, Fernanda Geraldes1, Margarida Figueiredo-Dias1,2\n1Gynecology Department, Universitary Hospital Center of Coimbra, Portugal\n2Universitary Clinic of Gynecology, Faculty of Medicine, University of Coimbra, Portugal\nEndometriosis has been considered an estrogen-dependent chronic inflammatory disease affecting women of reproductive age. Recent evidence suggests a shift in \nthis paradigm, considering the possible occurrence of de novo endometriosis diagnosis in postmenopausal women. The present study aims to help understanding \nthe pathophysiology and clinical management of such enigmatic entity after menopause. A total of 208 patients with histologic proven endometriosis were included \nin this cross-sectional study. Pearson linear correlations with collected data were performed using IBM® Cloud Pack ® For Data and further descriptive statistics \nwas made using IBM® SPSS® v26. The study sample included 6 cases of postmenopausal de novo endometriosis, which represents a 2.88% prevalence. Patients \nmean age at diagnosis was 56 years [50-79] . Only 16.3% (n = 1) was using menopausal hormone therapy (MHT) and, interestingly, a strong positive correlation \nwas observed between MHT and pelvic pain symptoms (r = 1). Ovarian localization was observed in 83.3% of the sample. Nevertheless, no positive correlation \nwas observed between CA-125 serum values and postmenopausal endometriosis (r = -0.15) comparing to premenopausal women (r = 0.39). The results of this \nstudy are in accordance to previous evidence on the subject, highlighting that endometriosis is a rare and poorly understood condition in postmenopausal women. \nManagement of endometriosis in symptomatic menopausal women and risk of malignant transformation remain uncertain. The growing awareness on this topic \nmakes the need for high-quality studies a certainty.\nBiography\nMariana Robalo Cordeiro has completed her Master Degree in Medicine at the age of 24 years from Faculty of Medicine of the University of Coimbra and has a \nPost-graduation in Artificial Intelligence in Healthcare from Massachusetts Institute of Technology. She is a Gynecology and Obstetrics Resident at Universitary \nHospital Center of Coimbra                                                                                                           \nmarianarobalocordeiro@gmail.com","source_license":"CC0","license_restricted":false}