{"paper_id":"b7f3857b-8bd3-4d76-88c4-20b41b70af24","body_text":"口服避孕药对延缓子宫内膜异位症疼痛进展的作用\nRole of oral contraceptives in preventing endometriosis-related pain progression\n摘要目的 分析口服避孕药对子宫内膜异位症患者疼痛的作用.方法 制订《痛经及慢性盆腔痛调查表》,入组对象为2014年2月至2016年2月期间就诊于北京大学第三医院妇科门诊的痛经患者,伴或不伴子宫内膜异位症或子宫腺肌症,将患者根据自身意愿分为研究组和对照组,研究组周期性服用口服避孕药(达英-35或优思明),对照组不作处理.每6个月随访患者的痛经情况,共随访1年半.结果 研究组服药6个月及1年后痛经评分均较前明显减低(VAS评分4比5比7分),停药后痛经评分再次上升,但仍较基线痛经评分有所减低(VAS评分6.5比7分);而对照组痛经评分前后无明显变化(VAS评分6比6分).研究组中服药达1年者服药6个月后痛经评分与服药1年后差异无统计学意义(VAS评分2比2分),停药后痛经缓慢加重,服药仅6个月者停药后痛经迅速复发.研究组服药后痛经缓解率明显高于对照组[79.7％ (59/74)比8.2％ (19/232)],服药后重度痛经患者痛经缓解率明显高于轻、中度痛经患者[87.0％(20/23)比66.7％(2/3)比77.1％ (37/48)];单纯痛经组痛经缓解率高于合并腺肌症组[92.6％ (25/27)比59.1％ (13/22)].结论 子宫内膜异位症是一种进展性疾病,长期服用口服避孕药可使痛经缓解.服药时间长短与痛经缓解程度无关.停药后痛经逐渐复发,服药时间越长,停药后痛经复发越慢.单纯痛经患者用药后痛经缓解率较高,合并子宫腺肌症者较低.\n更多相关知识\nabstractsObjective To analyze the effect of oral contraceptives on dysmenorrhea in patients with endometriosis.Methods We designed dysmenorrhea and chronic pelvic pain questionnaire.From February 2014 to February 2016 in the Gynecological Department of Peking University Third Hospital,patients suffered dysmenorrhea with or without endometriosis or adenomyosis were included.According to their own willingness,patients were divided into the research group and the control group.The research group periodically took oral contraceptives (Diane-35 or Yasmin),while the control group received no treatment.They were followed-up about dysmenorrhea every six months,and the total follow-up time was one and a half year.Results The dysmenorrhea VAS scores of patients in research group after taking oral contraceptives for six or twelve months were significantly lower than that in baseline (VAS 4 vs 5 vs 7).The dysmenorrhea VAS scores increased after quitting medication,but remained still lower than baseline (VAS 6.5 vs 7).However,the dysmenorrhea VAS scores of patients in control group remained unchanged (VAS 6 vs 6).Patients who took pills for more than one year experienced the same severity of dysmenorrhea after six months' or one year's medication (VAS 2 vs 2),and they suffered slowly aggravating recurrent dysmenorrhea,while those who quitted after six months' medication suffered quickly recurrent dysmenorrhea.The relieving rate of dysmenorrhea in research group was significantly higher than that in control group (79.7％ vs 8.2％),and the relieving rate in patients with severe pain was significantly higher than that with mild or moderate pain (87.0％ vs 66.6 ％ vs 77.1％).The relieving rate in patients without lesions was significantly higher than patients with adenomyosis (92.6％ vs 59.1％).Conclusions Endometriosis is a progressing disease.Longterm medication of oral contraceptives can relieve the dysmenorrhea pain.The extent of pain relief was not connected with the length of medication.Dysmenorrhea recurred after quitting medication,and the longer of medication,the slower pain recurred.Patients without lesions experienced higher pain relieving rate than those with adenomyosis.\nMore相关知识\n- 浏览0\n- 被引17\n- 下载0\n相似文献\n- 中文期刊\n- 外文期刊\n- 学位论文\n- 会议论文","source_license":"CC0","license_restricted":false}