{"paper_id":"b5e5e9aa-b076-4e97-a10f-4f71eca60e36","body_text":"Abstract\nInitially described as an antiobesity hormone, leptin has subsequently been shown also to influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune homeostasis. Leptin links nutritional status and proinflammatory T helper 1 immune responses, and the decrease in leptin plasma concentration during food deprivation leads to impaired immune function. This review focuses on the multiple roles of leptin in chronic inflammation and autoimmunity and suggests new possible therapeutic implications for leptin modulators.\nSimilar content being viewed by others\nAbbreviations\n- EAE :\n-\nExperimental autoimmune encephalomyelitis\n- IFN :\n-\nInterferon\n- IL :\n-\nInterleukin\n- Th :\n-\nT helper\n- TNF :\n-\nTumor necrosis factor\nReferences\nFriedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. 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Clin Rheumatol 18:394–401\nAcknowledgements\nThis work is partly supported by Fondazione Italiana Sclerosi Multipla and Comitato Trenta Ore per la Vita (Mediaset). A.L.C. is supported by the Arthritis National Research Foundation, the Lupus Foundation of America, and the California Community Foundation. This work is dedicated to the memory of Prof. Antonino Di Tuoro.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nLa Cava, A., Alviggi, C. & Matarese, G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 82, 4–11 (2004). https://doi.org/10.1007/s00109-003-0492-1\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00109-003-0492-1","source_license":"public-domain-us","license_restricted":false}