{"paper_id":"b564d117-0e1f-40c9-8895-523ffd8a3885","body_text":"- Preimplantation Genetic Diagnosis\n- Preimplantation Genetic Diagnosis\n- Copyright page\n- Contents\n- Contributors\n- Preface\n- Section 1 Background\n- Chapter 1 Introduction to preimplantation genetic diagnosis\n- Chapter 2 Assisted reproductive technologies\n- Chapter 3 Genetic basis of inherited disease\n- Chapter 4 Genetic counseling\n- Prenatal screening and diagnosis\n- Chapter 6 Preimplantation embryo development\n- Chapter 7 Preimplantation genetics\n- Section 2 Procedures used in preimplantation genetic diagnosis\n- Section 3 Ethics and the future\n- Index\nfrom Section 1 - Background\nPublished online by Cambridge University Press: 09 November 2009\nEdited by\nBook contents\n- Preimplantation Genetic Diagnosis\n- Preimplantation Genetic Diagnosis\n- Copyright page\n- Contents\n- Contributors\n- Preface\n- Section 1 Background\n- Chapter 1 Introduction to preimplantation genetic diagnosis\n- Chapter 2 Assisted reproductive technologies\n- Chapter 3 Genetic basis of inherited disease\n- Chapter 4 Genetic counseling\n- Prenatal screening and diagnosis\n- Chapter 6 Preimplantation embryo development\n- Chapter 7 Preimplantation genetics\n- Section 2 Procedures used in preimplantation genetic diagnosis\n- Section 3 Ethics and the future\n- Index\nA number of research and clinical studies have confirmed high frequency of cytogenetic abnormalities in human oocytes and embryos. Chromosomal imbalance in oocytes can result from loss or gain of individual chromatids or whole chromosomes. The underlying causes remain to be fully elucidated, but important modifying factors include the number and location of chiasmata and maternal age. Aneuploidy is a major cause of congenital abnormalities, mental retardation, and miscarriage. However, most of the chromosome abnormalities detected in human embryos are likely to be lethal at very early embryonic stages, and are probably incompatible with the formation of a clinical pregnancy. Many fertility clinics now screen the embryos produced during in vitro fertilization (IVF) cycle in order to identify those that are chromosomally normal. Screening the oocytes/embryos from these patients for aneuploidy using PGS may be particularly beneficial in terms of IVF outcome.\n- Type\n- Chapter\n- Information\n- Preimplantation Genetic Diagnosis , pp. 137 - 150Publisher: Cambridge University PressPrint publication year: 2009\nAccessibility compliance for the HTML of this chapter is currently unknown\nand may be updated in the future.\nTo save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.\nNote you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.\nFind out more about the Kindle Personal Document Service.\n- Preimplantation genetics\n-\n- Book: Preimplantation Genetic Diagnosis\n- Online publication: 09 November 2009\nTo save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.\n- Preimplantation genetics\n-\n- Book: Preimplantation Genetic Diagnosis\n- Online publication: 09 November 2009\nTo save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.\n- Preimplantation genetics\n-\n- Book: Preimplantation Genetic Diagnosis\n- Online publication: 09 November 2009","source_license":"CC0","license_restricted":false}