{"paper_id":"b5631a49-8b52-4ea4-8923-9a06aa7e8a77","body_text":"Abstract\nPurpose\nTo elucidate the role of retinoic acid (RA) in autophagy-mediated endometriosis.\nMethods\nThe mRNA and protein expressions of autophagy markers were examined in Ishikawa cells and endometriotic stromal cells (ESCs) after RA treatment. Beclin1 expression was specifically analyzed in clinical samples of endometriosis. The effect of Beclin1 knockdown on ESC growth was assessed, and the effect of autophagy inhibition on the sensitivity of endometriotic cells to RA was analyzed.\nResults\nRA treatment enhanced the autophagy in ESCs, and Beclin1 expression showed a negative correlation with the clinical stage of endometriosis. Beclin1 knockdown enhanced ESC growth, whereas RA treatment reversed this effect. 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Retinoic acid regulates endometriotic stromal cell growth through upregulation of Beclin1. Arch Gynecol Obstet 297, 93–99 (2018). https://doi.org/10.1007/s00404-017-4549-8\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-017-4549-8","source_license":"CC0","license_restricted":false}