{"paper_id":"b520a1f9-b439-4f77-991a-934098798a7c","body_text":"Print ISSN: 1021-335X\nOnline ISSN: 1791-2431\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 1235-1239|Published online on: June 1, 2005https://doi.org/10.3892/or.13.6.1235\n- Expand metrics +\nDecreased numbers of eutopic endometrial apoptotic cells have been reported in endometriotic patients, indicating the possibility of anti-apoptotic effects of their sera. Recently, we reported that the sera from endometriotic patients enhance endometrial stromal cell proliferation and viability, and that Keishi-bukuryo-gan therapy, an anti-endometriotic Japanese herbal medicine, reduces anti-apoptotic activities in the sera. In this study, we therefore examined the effects of sera from 7 endometriotic patients on cell proliferation and Fas-mediated apoptosis of the human endometrial epithelial cell line HHUA, which has a normal karyotype and functional estrogen and progesterone receptors. Cell proliferation was not affected by any of the sera examined, including sera from healthy women. The sera of 6 out of 7 endometriotic patients and sera from 2 healthy women significantly inhibited Fas-mediated apoptosis in the cells. Moreover, anti-apoptotic activities in the sera of endometriotic patients on Fas-mediated apoptosis were not affected by gonadotropin-releasing hormone agonist (GnRHa) therapy within 4 weeks or Keishi-bukuryo-gan therapy within 12 weeks. Considering these results, we suggest that the surviving factor(s) against Fas-mediated endometrial epithelial cell apoptosis in human sera can be found in endometriotic and non-endometriotic women, and that decreased eutopic endometrial epithelial apoptosis in endometriotic patients might be caused by the secondary effects of endometrial stromal cell growth and surviving factor(s) in sera of the patients, not by direct serum effects on the epithelium.\nCopy and paste a formatted citation\nSpandidos Publications style\nTanaka T: Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis. Oncol Rep 13: 1235-1239, 2005.\nAPA\nTanaka, T. (2005). Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis. Oncology Reports, 13, 1235-1239. https://doi.org/10.3892/or.13.6.1235\nMLA\nTanaka, T.\"Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis\". Oncology Reports 13.6 (2005): 1235-1239.\nChicago\nTanaka, T.\"Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis\". Oncology Reports 13, no. 6 (2005): 1235-1239. https://doi.org/10.3892/or.13.6.1235","source_license":"CC0","license_restricted":false}