{"paper_id":"b512fa18-73e2-4bf7-b99b-615026725824","body_text":"Summary\nIn a randomized study, the effect of gestrinone (2×2,5 mg/week) was compared with the effect of danazol (3×100 mg/day) in treating 30 patients with laparoscopically proven endometriotic implants for 6 months. Therapy was effective in 80%–90% of cases and pregnancy rates were similar but the incidence of side effects was different in the groups. In addition, buserelin (900 μg/day intranasally) was investigated in a multinational, multicenter trial in 275 patients. In 80%, GnRH agonsit treatment induced the disappearance or reduction of endometriotic implants. The main side effects were due to estrogenic suppression. Presently, various methods of hormonal treatment, are under investigation, especially to determine recurrency rates of endometriosis and long-term side effects.\nZusammenfassung\nIn einer randomisierten Studie wurden bei 30 Patientinnen 6 Monate lang die Wirkungen von Gestrinon (2×2,5 mg/Woche) und Danazol (3×200 mg/Tag) verglichen. Bei erfolgreicher Therapie in 80–90% der Fälle und ähnlicher Schwangerschaftsrate traten in beiden Gruppen jedoch unterschiedliche Nebenwirkungen auf. Zusätzlich wurde, Buserelin in einer multinationalen multizentrischen Studie an 275 Patientinnen mit intranasalen Gaben von 900 μg/Tag untersucht. Bei 80% führte die Behandlung mit dem GnRH-Agonisten zum Abheilen oder zum Rückgang der Implantate Die hauptsächlichen Nebenwirkungen waren auf die Östrogensuppression zurückzuführen. Zur Zeit werden verschiedene Methoden im Hinblick auf Rezidivraten und Langzeit-Nebenwirkungen getestet.\nSimilar content being viewed by others\nLiteratur\nCirkel U, Schweppe KW, Ochs H, Schneider HPG (1987) Metabolische Effekte und allgemeine Nebenwirkungen bei Endometriosebehandlung mit einem LHRH-Agonisten. Geburtsh Frauenheilk 47: 154–157\nCornillie FJ, Vasquez G, Brosens I (1985) The response of human endometriotic implants to the anti-progesterone steroid R 2323: a histologic and ultrastructural study. Path Res Pract 180: 647–655\nDlugi AM, Rufo S, D'Amico JF, Seibel MM (1988) A comparison of the effects of Buserelin versus danazol on plasma lipoproteins during treatment of pelvic endometriosis. Fertil Steril 49: 913–916\nDonnez J, Lemaire-Rubbers M, Karaman Y, Nisolle-Pochet M, Casanas-Roux F (1987) Combined (hormonal and microsurgical) therapy in infertile women with endometriosis. Fertil Steril 48: 239–242\nHardt W, Schmidt-Gollwitzer M, Schmidt-Gollwitzer K, Genz T, Nevinny-Stickel J (1986) Initial results in the treatment of endometriosis with the LHRH analogue buserelin. Geburtsh Frauenheilk 46: 483\nHenzl MR, Corson SL, Moghissi K, Buttram VC, Berquist C, Jacobson J (1988) Administration of nasal nafarelin as compared with oral danazol for endometriosis. N Engl J Med 318: 485–489\nKiesel L, Bertges K, Rabe T, Runnebaum B (1986) Gonadotropin releasing hormone enhances polyphosphoinositide hydrolyis, in rat pituitary cells. Biochem Biophys Res Commun 134: 861\nKiesel L, Catt KJ (1987) Stimulation of luteinizing hormone release and cyclic nucleotide production by arachidonic acid in cultured gonadotrophs. Neuroendocrinology 46: 1\nKiesel L, Kaufmann M, Haeseler F, Klinga K, von Holst T, Schmidt W, Runnebaum B (1988) GnRH receptors in human breast cancer tissue. Geburtsh Frauenheilk 48: 420–424\nLemay A, Maheux R, Faure N, Jean C, Fazekas ATA (1984) Reversible hypogonadism induced by luteinizing hormone releasing hormone (LHRH) agonist (buserelin) as a new therapeutic approach for endometriosis. Fertil Steril 41: 863\nMettler L (1987) Vergleich der medikamentösen Behandlung der Endometriosis genitalis externa mit Gestrinon, Lynestrenol und Danazol im Rahmen der Drei-Stufen-Behandlung. Fertilität 3: 133–139\nSchneider HPG, Schweppe K-W, Cirkel U, Ochs H (1986) Management of endometriosis. In: Rolland R, Chadha DR, Willemsen WNP (eds) Gonadotropin Down-Regulation in Gynecological Practice. Progr Clin Biol Res vol 225. Alan R Liss, New York, pp 135–156\nSchweppe K-W (1984) Morphologie und Klinik der Endometriose. Schattauer, Stuttgart New York\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nKiesel, L., Bertges, K., Rabe, T. et al. Therapie der Endometriose. Arch Gynecol Obstet 245, 937–940 (1989). https://doi.org/10.1007/BF02417628\nIssue date:\nDOI: https://doi.org/10.1007/BF02417628","source_license":"CC0","license_restricted":false}