{"paper_id":"b2fcba71-4d55-417f-bd49-0d52bce03a85","body_text":"The Iron-Lock Loop: A Self-Sustaining Disease Circuit in Endometriosis — Clinical Systems Analysis with Cross-Disease Extension\nAuthors/Creators\nDescription\nThis document proposes that endometriosis is maintained by a four-node self-sustaining biological circuit — the Iron-Lock Loop — connecting Fusobacterium nucleatum, IL-6/hepcidin dysregulation, peritoneal iron accumulation, and bacterial sanctuary formation. Each node is individually published across separate literatures. The synthesis and the multi-node simultaneous intervention protocol are new. A companion document extends the same circuit architecture to six additional conditions: schizophrenia, epilepsy, Parkinson's disease, multiple sclerosis, cancer, and HIV/AIDS. All claims are falsifiable research hypotheses. Nothing in either document constitutes clinical advice.\nNotes (English)\nFiles\nFiles\n(67.0 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:275754bfccdc06722147adcf60108229\n|\n30.5 kB | Download |\n|\nmd5:318cef586b4f76fbb323acde04886e6f\n|\n36.5 kB | Download |\nAdditional details\nIdentifiers\nRelated works\n- Is supplement to\n- Report: 10.5281/zenodo.20303520 (DOI)\n- Report: 10.5281/zenodo.20394568 (DOI)\nDates\n- Submitted\n-\n2026-05-20","source_license":"CC0","license_restricted":false}