{"paper_id":"b19a793a-0c51-4fac-a3e4-76c2e081ee80","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 865-869|Published online on: May 1, 2005https://doi.org/10.3892/ijmm.15.5.865\n- Expand metrics +\nAlthough the pathophysiological mechanisms leading to endometriosis remain unknown, several hypothesis have been proposed, including a dysregulation of the normal apoptotic process which takes place in the endometrium. One of the apoptotic pathways playing a crucial role in the programmed cell death within the endometrium is the Fas-FasL system. In this study we have performed a case-control analysis in order to evaluate three polymorphisms located within FAS (-1377G>A and -670A>G) and FASL (-843C>T) genes, as susceptibility factors for endometriosis. We have analysed a series of women with endometriosis compared respectively to a group of women without symptoms of the disease, and to a group of confirmed unaffected women. The genotyping of the three variants was carried out by Fluorescence Resonance Energy Transfer (FRET) technology, and statistical analysis was performed using χ2 test with Yates correction. Our results show that the differences in the distribution of the polymorphic variants were not statistically significant when the group of patients was compared to the other groups. Thus, it seems to indicate that the variants here analysed are not involved in the pathogenesis of the disease in our population. However this does not let us to completely exclude such genes as potential candidates for the disease. A complete genetic analysis of the genes involved in the intricate regulatory system of the apoptosis may lead to the identification of susceptibility factors for the disease and a better understanding of its etiology.\nCopy and paste a formatted citation\nSpandidos Publications style\nFernández RM, Noval JA, García-Lozano JC, Borrego S, Moliní JL and Antiñolo G: Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis. Int J Mol Med 15: 865-869, 2005.\nAPA\nFernández, R.M., Noval, J.A., García-Lozano, J.C., Borrego, S., Moliní, J.L., & Antiñolo, G. (2005). Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis. International Journal of Molecular Medicine, 15, 865-869. https://doi.org/10.3892/ijmm.15.5.865\nMLA\nFernández, R. M., Noval, J. A., García-Lozano, J. C., Borrego, S., Moliní, J. L., Antiñolo, G.\"Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis\". International Journal of Molecular Medicine 15.5 (2005): 865-869.\nChicago\nFernández, R. M., Noval, J. A., García-Lozano, J. C., Borrego, S., Moliní, J. L., Antiñolo, G.\"Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis\". International Journal of Molecular Medicine 15, no. 5 (2005): 865-869. https://doi.org/10.3892/ijmm.15.5.865","source_license":"CC0","license_restricted":false}