{"paper_id":"af44c9c3-11ba-4884-8cf8-4778756ffa04","body_text":"12 June 2019 : Clinical Research\nEfficacy and Safety of In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Among Patients with Endometriosis After a Shortened Protocol of Long-Term Pituitary Downregulation\nHuijuan Kong1ABEF, Zhiqin Bu1DEF, Yihong Guo1AD, Fang Wang1F, Hao Shi1CD, Linli Hu1F, Yingpu Sun1A*DOI: 10.12659/MSM.916447\nMed Sci Monit 2019; 25:4377-4383\nAbstract\nBACKGROUND: Patients with endometriosis (EMs) are routinely advised to take GnRH-a for 3–6 months to improve the internal reproductive environment, but this may not be necessary.\nMATERIAL AND METHODS: This retrospective study examined the effects of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) with shortened (n=311) or conventional (n=213) long-term pituitary downregulation in EMs patients between January 2013 and July 2017.\nRESULTS: The 2 groups showed no significant differences in gonadotropin (Gn) dose, number of oocytes retrieved, or miscarriage rate. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels on the initiation day and the LH level on human chorionic gonadotropin (hCG) day (1.22±1.39 vs. 0.74±0.55 P=0.0026) were higher in the study group than in the control group. The cumulative live birth rates in the second cycle were 69.13% in the study group (95% confidence interval (CI), 64–74.27%) vs. 68.54% in the control group (95% CI, 62.31–74.78%, P=0.88, respectively).\nCONCLUSIONS: This study showed that the shortened regimen and the ultralong regimen did not produce different pregnancy outcomes after ART, and the single-application, long-term GnRH-a protocol may serve as a cost-effective and safe treatment protocol for EMs patients.\nKeywords: Endometriosis, Fertilization in Vitro, Gonadotropin-Releasing Hormone, Pregnancy Rate, Abortion, Spontaneous, Chorionic Gonadotropin, Down-Regulation, Embryo Transfer, Oocyte Retrieval, Oocytes, Ovulation Induction, Pituitary Gland, Pregnancy, Pregnancy Outcome, Sperm Injections, Intracytoplasmic\nEditorial\n01 January 2026 : Editorial\nEditorial: Increasing Awareness of Lung Cancer in Non-Smokers and Never-Smokers Challenges Current Approaches to Prevention and ScreeningDOI: 10.12659/MSM.952454\nMed Sci Monit 2026; 32:e952454\nIn Press\nClinical Research\nInstitutional and Regional Variations in Access to Clinical Trials and Next-Generation Sequencing in Turkis...Med Sci Monit In Press; DOI: 10.12659/MSM.951027\nClinical Research\nLow-Intensity Blood Flow-Restricted Multi-Joint Exercise Improves Muscle Function in Patients With Patellof...Med Sci Monit In Press; DOI: 10.12659/MSM.950516\nReview article\nMusculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.951283\nClinical Research\nSensory Processing, Dissociation, and Affective Symptoms in Misophonia: A Cross-Sectional Study of 35 AdultsMed Sci Monit In Press; DOI: 10.12659/MSM.950938\nMost Viewed Current Articles\n17 Jan 2024 : Review article 10,187,196\nVaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799\nMed Sci Monit 2024; 30:e942799\n13 Nov 2021 : Clinical Research 3,708,487\nAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788\nMed Sci Monit 2021; 27:e932788\n14 Dec 2022 : Clinical Research 2,341,643\nPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990\nMed Sci Monit 2022; 28:e937990\n16 May 2023 : Clinical Research 706,524\nElectrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387\nMed Sci Monit 2023; 29:e940387","source_license":"CC0","license_restricted":false}