{"paper_id":"af0bd54e-545d-4443-b011-5838a5dcd6bf","body_text":"МІНІСТЕРСТВО ОХОРОНИ ЗДОРОВ’Я УКРАЇНИ \nБУКОВИНСЬКИЙ ДЕРЖАВНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ» \n \nМ А Т Е Р І А Л И \n105-ї підсумкової науково-практичної конференції \nз міжнародною участю \nпрофесорсько-викладацького персоналу \nБУКОВИНСЬКОГО ДЕРЖАВНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ \nприсвяченої 80-річчю БДМУ \n05, 07, 12 лютого 2024 року \n \n \nКонференція внесена до Реєстру заходів безперервного професійного розвитку,  \nякі проводитимуться у 2024 році № 3700679 \n \n \n \n \n \n \n \n \n \nЧернівці – 2024 \n\n\n2 \n \nУДК 001:378.12(477.85) \nББК 72:74.58  \nМ 34 \n \nМатеріали підсумкової 105-ї науково-практичної конференції з міжнародною \nучастю професорсько -викладацького персоналу Буковинського державного \nмедичного університету, присвяченої 80 -річчю БДМУ  (м. Чернівці,                 \n05, 07, 12 лютого 2024 р.) – Чернівці: Медуніверситет, 2024. – 477 с. іл. \n \nББК 72:74.58 \n \nУ збірнику представлені матеріали 105-ї підсумкової науково-практичної \nконференції з міжнародною участю професорсько-викладацького персоналу \nБуковинського державного медичного у ніверситету, присвяченої 80 -річчю \nБДМУ (м. Чернівці, 05, 07, 12 лютого 2024 р.) із стилістикою та орфографією \nу авторській редакції.  Публікації присвячені актуальним проблемам \nфундаментальної, теоретичної та клінічної медицини. \n \n \nЗагальна редакція : професор Геруш І.В., професор ка Грицюк М.І.,               \nпрофесор Безрук В.В. \n \n \nНаукові рецензенти:  \nпрофесор Братенко М.К. \nпрофесор Булик Р.Є. \nпрофесор Гринчук Ф.В. \nпрофесор Давиденко І.С. \nпрофесор Дейнека С.Є. \nпрофесорка Денисенко О.І. \nпрофесор Заморський І.I. \nпрофесорка Колоскова О.К.  \nпрофесор Коновчук В.М. \nпрофесор Пенішкевич Я.І. \nпрофесорка Хухліна О.С. \nпрофесор Слободян О.М. \nпрофесорка Ткачук С.С. \nпрофесорка Тодоріко Л.Д. \nпрофесор Юзько О.М. \nпрофесорка Годованець О.І. \n \n \nISBN 978-617-519-077-7  © Буковинський державний медичний  \n    університет, 2024 \n\n232 \n \naccount pregnant women of the risk group for the development of preeclampsia detailed collection \nand analysis of obstetric anamnesis, identification of risk groups pregnant women and timely \npreventive treatment for the purpose of prevention occurrence of this pathology. \n \nBakun O.V. \nROLE OF LACTOBACTERIA AT ENDOMETRIOSIS \nDepartment of Obstetrics and Gynecology \nBukovinian State Medical University \nIntroduction. For the first time, the term “probiotics” was proposed in 1954 by F. Vergio, \nwho conducted comparison of various compounds characterized by antimicrobial and positive \neffects on intestinal microflora. In particular, they contribute to the breakdown of mil k sugar in the \ncase lactose malabsorption, prevention of diarrhea, increase in the content of enzymes in the large \nintestine, which stimulate the immune system. These are also substances of microbial or of non -\nmicrobial origin, which with the natural metho d of administration contribute to homeostasis due to \nthe normalization of microflora in the body; means of maintaining intestinal balance microflora at \nan optimal level and its correction. Lactobacilli participate in the synthesis of antibodies and \ninteract with white blood cells that serve to maintain immunity in general. \nThe aim of the study. To investigate role of lactobacteria at endometriosis according \nliterature data. \nMaterial and methods. In a study by a group led by Hiroyuki, treatment with oral \nLactobacillus gasseri OLL2809 was used at experimental endometriosis in mice. The authors \nobtained the result of suppression of the development of experimental endometriosis, explaining \nthis by the ability of lactobacilli to stimulate IL -12-induced NK activation. In 2011, the same group \nof authors published the results of a double randomized, placebo -controlled study of the effect of \nLactobacillus gasseri OLL2809 on the severity of menstrual pain and manifestations of \ndysmenorrhea in women with endometriosis associated with infertility. \nAs in the previous study, this study used an oral probiotic, and the results were evaluated on \na point scale and showed a probable reduction in pain and dysmenorrhea after taking the \nLactobacillus preparation. In addition, this group of scientists conducted monitoring of the course \nendometriosis by monitoring the level of CA -125 in the blood, which also showed probable \ndecrease. The results obtained by the aforementioned group of authors also explains from the \nstandpoint of NK ac tivation and their destruction of endometrioid foci ectopy cytotoxic activity of \nNK isolated from women with endometriosis, associated with infertility, in relation to endometrioid \nculture cells, which in itself was a major breakthrough for the prospect th e use of bacteria in the \ncomplex treatment of endometriosis. \nThis effect of NK stimulation by bacterial agents followed by a decrease manifestations of \nendometriosis was shown even earlier on the example of mycobacteria. In 2004, R.D. Clayton and \nSang showed the ability of mycobacteria to increase cytotoxic activity of NK isolated from women \nwith endometriosis, associated with infertility, in relation to endometrioid culture cells, which in \nitself was a major breakthrough for the prospect the use of bacteri a in the complex treatment of \nendometriosis. \nResults. The obtained results can be explained by relying on the known studies of many \nscientists, in particular H. Itoh et al. (2011) who state that drugs lactobacilli have a significant \nability to cause NK act ivation, with amplification synthesis of IL -12, while reducing excessive \nsynthesis of pro-inflammatory TNF-α, IL-2, IL-1β, IL-6 (definitely transplant induced, why there is \nother scientific evidence) and, which is of particular importance - VEGF, because this growth factor \nis recognized as one of the main culprits of endometrioid growth. In general, the results coincided \nwith the following in the group by H. Itoh (2011), despite methodological differences, assessment \napproaches and methods and other works describing the anti-inflammatory potential of lactobacilli. \nThe research data can be considered as a positive result of preclinical use of probiotics \ncontaining lactobacilli for the treatment of endometriosis.  \n\n233 \n \nConclusions. Therefore, it can be argued that lactobacillus preparations have significant \nability to cause NK activation, with increased synthesis of IL -12 These research data can be \nconsidered as a positive result of preclinical the use of probiotics containing lactobacilli for the \ntreatment of endometriosis. \n \nBerbets A.M. \nPREGNANCY COMPLICATIONS AND MELATONIN CHANGES IN CASE OF SLEEP \nDISORDERS PRESENCE \nDepartment of Obstetrics and Gynecology \nBukovinian State Medical University, Chernivtsi, Ukraine \nIntroduction. The pineal gland produces the important hormone melatonin, which \nmaintains the human body's circadian rhythm. Melatonin is also produced by the placenta in \npregnant women. The effect of melatonin deficiency in case of pregnancy disorders, such as \nintrauterine growth restriction (IUGR) of fetus and preeclampsia (PE), has been insufficiently \nstudied. \nThe aim of the study:  to research the available data concerning sleep disorders at \npregnancy and their clinical significance.  \nMaterial and methods. We analyzed the recent publications dedicated to the problem. \nResults. In analyzed papers, the relevant information is presented as follows: the morning \nconcentration of melatonin in the blood of pregnant women with IUGR significantly reduces, \ncompared to healthy pregnant women, which authors cons ider to be caused mostly by placental \ndysfunction. Changes in the functioning of the pineal gland in patients with IUGR are clinically \nexpressed as sleep disorders and confirmed by a significant decrease of melatonin concentrations in \nsaliva taken at night, in comparison with women with non-complicated pregnancies. Sleep disorders \nin women with IUGR manifest early during pregnancy, mostly during 22 nd–30th week. Changes in \nmelatonin concentrations in such patients are accompanied by the lowering of the concentrations of \nplacental growth factor (PlGF) in blood and with increase of the blood levels of cytokines, namely \nproinflammatory TNF-α, IL-1-β and IL-6, compared to healthy pregnant women. In placental tissue \nmelatonin receptors 1A and 1B are significantly less expressed in the case that pregnancy is \ncomplicated with IUGR, which is confirmed by changes in the optical density of these receptors. \nIn publicat ions dedicated to preeclampsia, it is stated that the morning concentrations of \nmelatonin and PlGF were also significantly lower in the blood of women with PE compared to \nhealthy pregnant women. The authors suggest that alterations in the placental product ion of \nmelatonin and PlGF may contribute to the development of preeclampsia. In contrast, higher levels \nof the pro -inflammatory cytokine interleukin -6 (IL -6) and the anti -inflammatory cytokine \ninterleukin-10 (IL -10) were observed in preeclampsia patients' blood, compared to the healthy \npregnant women. Significant sleep disorders were also described in patients with PE. \nConclusions. Melatonin is a hormone that plays a very important role in the mechanisms of \ndevelopment of such pregnancy complications as IUG R and PE. Further studies are needed to \ndescribe its role in the pathways of mentioned disorders of human pregnancy. Sleep disorders, if \npresent in a pregnant patient, should not be ignored by clinicians. \n \nDubyk L.V. \nRISK GROUPS OF RECURRENT PREGNANCY LOSS \nDepartment of Obstetrics and Gynecology \nBukovinian State Medical University \nIntroduction. Pregnancy loss is a spontaneous loss of a pregnancy. According to the World \nHealth Organization (WHO), the frequency of an early pregnancy loss is 20 to 25%. A diagnosis of \nRecurrent Pregnancy Loss (RPL) could be considered after the loss of two or more p regnancies. \nThis includes pregnancies after spontaneous conception and after assisted reproduction. It is \nestimated that RPL affects 1 to 2% of couples.  Around half of all the fertilized eggs die and are lost \n(aborted) spontaneously, usually before the wom an knows she is pregnant. Among women who","source_license":"CC0","license_restricted":false}