{"paper_id":"ac7cb9ff-77f0-4584-80fb-c8afbb54d7b5","body_text":"Evaluation of survivin expression in the endometrium and endometriotic lesions in patients with genital endometriosis, type 1 diabetes mellitus and their comorbidity\n- Authors: Andreeva N.Y.1, Yarmolinskaya M.I.1, Misharina E.V.1, Tolibova G.K.1, Semenova V.O.1\n-\nAffiliations:\n- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\n- Issue: Vol 72, No 3 (2023)\n- Pages: 5-13\n- Section: Original study articles\n- Submitted: 24.04.2023\n- Accepted: 25.05.2023\n- Published: 14.07.2023\n- URL: https://journals.eco-vector.com/jowd/article/view/345406\n- DOI: https://doi.org/10.17816/JOWD345406\n- ID: 345406\nCite item\nAbstract\nBACKGROUND: The prevalence of external genital endometriosis is high, yet there is insufficient understanding of its etiology and pathogenesis. This coupled with the challenges posed by its diagnosis and treatment, and its co-occurrence with type 1 diabetes mellitus, underscores the significance of this issue.\nAIM: The aim of this study was to evaluate the expression of survivin in the eutopic endometrium, endometriotic lesions, and their concomitant conditions in patients with external genital endometriosis and type 1 diabetes mellitus.\nMATERIALS AND METHODS: This study enrolled 43 female patients of reproductive age who were divided into four groups. The main group (n = 17) included women with surgically and histologically confirmed external genital endometriosis combined with type 1 diabetes mellitus. The external genital endometriosis group (n = 9) comprised women with isolated external genital endometriosis, while the type 1 diabetes mellitus group (n = 6) included patients with type 1 diabetes mellitus only. Finally, the control group (n = 6) consisted of women without any gynecological pathology. Biological specimens were collected during the follicular phase of the menstrual cycle, and morphological examination was carried out through histological and immunohistochemical evaluation of the endometrium and endometrioid heterotopias. Statistical analysis of the data was performed using the Jamovi software program, with statistical significance defined as p < 0.05.\nRESULTS: Our findings indicate that patients with external genital endometriosis and comorbid type 1 diabetes mellitus exhibit a statistically significant increase in survivin expression in the endometrium compared to the control group or patients with type 1 diabetes mellitus only. However, no significant difference was observed in survivin expression in endometriotiс lesions between patients with external genital endometriosis and those with external genital endometriosis combined with type 1 diabetes mellitus.\nCONCLUSIONS: The data obtained suggest the role of survivin in the pathogenesis of external genital endometriosis, regardless of the presence of type 1 diabetes mellitus.\nKeywords\nFull Text\nAbout the authors\nNelly Yu. Andreeva\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nAuthor for correspondence.\nEmail: nelly8352@yahoo.com\nORCID iD: 0000-0002-1928-1266\nSPIN-code: 3355-2646\nMD\nRussian Federation, Saint PetersburgMaria I. Yarmolinskaya\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: m.yarmolinskaya@gmail.com\nORCID iD: 0000-0002-6551-4147\nSPIN-code: 3686-3605\nScopus Author ID: 7801562649\nResearcherId: P-2183-2014\nMD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences\nRussian Federation, Saint PetersburgElena V. Misharina\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: mishellena@gmail.com\nORCID iD: 0000-0002-0276-7112\nSPIN-code: 7350-5674\nScopus Author ID: 57200069538\nResearcherId: K-2720-2018\nMD, Cand. Sci. (Med.)\nRussian Federation, Saint PetersburgGulrukhsor Kh. Tolibova\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: gulyatolibova@mail.ru\nORCID iD: 0000-0002-6216-6220\nSPIN-code: 7544-4825\nScopus Author ID: 23111355700\nResearcherId: Y-6671-2018\nMD, Dr. Sci. (Med)\nRussian Federation, Saint PetersburgValeriia O. Semenova\nThe Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott\nEmail: pyankova.valeriia@rambler.ru\nORCID iD: 0000-0002-9101-1981\nSPIN-code: 1422-8060\nScopus Author ID: 57863306500\nResearcherId: HKF-5961-2023\nMD\nRussian Federation, Saint PetersburgReferences\n- Yarmolinskaya MI. Ailamazyan EK. Genital endometriosis — different facets of the issue. Saint Petersburg: Eco-Vector; 2017. (In Russ.)\n- Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis. Endocr Rev. 2019;40(4):1048–1079. doi: 10.1210/er.2018-00242\n- Shafrir AL, Farland LV, Shah DK, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018;(51):1–15. doi: 10.1016/j.bpobgyn.2018.06.001\n- Hemmert R, Schliep KC, Willis S, et al. Modifiable life style factors and risk for incident endometriosis. Paediatr Perinat Epidemiol. 2019;33(1):19–25. doi: 10.1111/ppe.12516\n- Sinaii N, Cleary SD, Ballweg ML, et al. 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