{"paper_id":"a8d77246-0357-4b00-a39f-23d35f068621","body_text":"Abstract\nBackground\nFew histopathologic studies of uterine wound healing have been published compared with similar healing in other tissues. Our objective was to examine the histopathology resulting from iatrogenic trauma to the myometrium to acquire a better understanding of possible aberrations in uterine wound healing.\nMethods\nWe studied paired injured myometrium and uninvolved myometrium from 7 hysterectomy specimens. All subjects had either abnormal bleeding or chronic pain following an iatrogenic injury to the myometrium. The time between the initial injury and hysterectomy ranged from 2 months to 13 years. Tissue was evaluated with hematoxylin and eosin (H&E) followed by Masson Trichrome staining for collagen, Weigert-Van Gieson elastic staining, and/or Kreyberg staining for fibrin and glycosaminoglycans or MIB-1 (Ki-67) immunhistochemistry for cell proliferation.\nResults\nHistopathologic examination of the 7 paired tissues revealed evidence of altered healing including myofiber disarray, elastosis, tissue edema, and inflammation. Small fibroids, myometrial hyperplasia, a keloid-like region of scar and adenomyosis were also observed.\nConclusions\nMyofiber disarray and elastosis may be markers of aberrancy in wound healing after iatrogenic uterine trauma. Altered myometrial scarring in these cases may have contributed to the clinical outcome necessitating hysterectomies. Myometrial hyperplasia in the region of the scars might also contribute to the clinical presentation as well. 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Myometrial hypertrophy-a clinical pathologic study and review of the literature. Am J Obstet Gynecol. 1962;84:1032–1041.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nRoeder, H.A., Cramer, S.F. & Leppert, P.C. A Look at Uterine Wound Healing Through a Histopathological Study of Uterine Scars. Reprod. Sci. 19, 463–473 (2012). https://doi.org/10.1177/1933719111426603\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719111426603","source_license":"CC0","license_restricted":false}