{"paper_id":"a623b872-dfef-40eb-9949-9f21890e2d30","body_text":"Abstract\nThere are several entities that can present with multiple nodular lesions within the peritoneal cavity, such as “disseminated peritoneal leiomyomatosis,” “peritoneal fibrosis,” “calcifying fibrous pseudotumor,” and the recently described lesion of “reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery.” Here we present one such lesion in a 28-year-old woman with a history of dysmenorrhea and ergotamine use for migraine attacks. Intraoperative exploration of our patient disclosed numerous nodules located throughout the pelvic and abdominal peritoneum. Histopathologically, these lesions were fibrocollagenous nodules composed of sparse wavy spindle cells within hyalinized “keloid-like” collagen surrounded by an inflammatory infiltrate. Some of the nodules were associated with small foci of endometriosis. We believe this lesion is best described by the term “reactive nodular fibrous pseudotumor” and that endometriosis and the use of ergotamine derivatives may be contributing factors.\nSimilar content being viewed by others\nReferences\nChatelain D, Manaouil D, Levy P, Joly JP, Sevestre H, Regimbeau JM (2004) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery. Am J Surg Pathol 28:416\nClement PB, Young RH, Hanna W, Scully RE (1994) Sclerosing peritonitis associated with luteinized thecomas of the ovary. A clinicopathological analysis of six cases. Am J Surg Pathol 18:1–13\nClement PB (1995) Reactive tumor-like lesions of the peritoneum. Am J Clin Pathol 103:673–676\nClement PB (2002) Diseases of the peritoneum. In: Kurman RJ (ed) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York, pp 731–732\nDaum O, Vanecek T, Sima R, Curik R, Zamecnik M, Yamanaka S, Mukensnabl P, Benes Z, Michal M (2004) Reactive nodular fibrous pseudotumors of the gastrointestinal tract: a report of 8 cases. Int J Surg Pathol 12:365–374\nItoga T, Matsumoto T, Takeuchi H, Yamasaki S, Sasahara N, Hoshi T, Kinoshita K (2003) Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis. Pathol Int 53:371–375\nNascimento AF, Ruiz R, Hornick JL, Fletcher CD (2002) Calcifying fibrous “pseudotumor”: clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor. Int J Surg Pathol 10:189–196\nRobert M, Derbaudrenghien JP, Blampain JP, Lamy F, Meyer P (1984) Fibrotic processes associated with long-term ergotamine therapy. N Engl J Med 311:601–602\nYantiss RK, Nielsen GP, Lauwers GY, Rosenberg AE (2003) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery: a clinicopathologic study of five cases. Am J Surg Pathol 27:532–540\nZaloudek C, Hendrickson MR (2002) Mesenchymal tumors of the uterus. In: Kurman RJ (ed) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York, pp 577–578\nZardawi IM, Catterall N, Cox SA (2004) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery. Am J Surg Pathol 28:276–277\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nSaglam, E.A., Usubütün, A., Kart, C. et al. Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch 447, 879–882 (2005). https://doi.org/10.1007/s00428-005-0027-y\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00428-005-0027-y","source_license":"CC0","license_restricted":false}