{"paper_id":"a57b8f50-2cc5-41c5-b6f7-811e295e6c05","body_text":"Abstract\nEndometriosis is a common reproductive system disease worldwide that mainly causes chronic pelvic pain and infertility. Despite its high prevalence, the diagnosis of some patients with endometriosis is delayed for several years, which may be because the gold standard for diagnosis is an expensive and invasive surgical assessment by laparoscopy or laparotomy. Circulating microRNAs (miRNAs) play an important role in a wide range of diseases, including endometriosis, and have been discovered to be potential diagnostic markers. This meta-analysis, which was designed to investigate the diagnostic value of circulating miRNAs for endometriosis, summarizes miRNA articles that met a set of inclusion criteria. Using a bivariate model, we calculated the sensitivities, specificities, and area under the curve (AUC) values of individual miRNAs and miRNA panels. The pooled diagnostic sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic (AUROC) curve were 0.86 (95% CI 0.79–0.90), 0.88 (95% CI 0.80–0.93), 7.05 (95% CI 4.20–11.84), 0.16 (95% CI 11–0.24), and 0.93, respectively. Taken together, these findings indicate that circulating microRNAs may serve as potential noninvasive biomarkers of endometriosis.\nSimilar content being viewed by others\nReferences\nBrosens I, Benagiano GJIJMR. Endometriosis, a modern syndrome. Indian J Med Res. 2011;133(6):581–93.\nVercellini P, Viganò P, Somigliana E, Fedele LJNRE. Endometriosis: Pathogenesis and Treatment. Nat Rev Endocrinol. 2014;10(5):261–75.\nLeyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. JAoG, Obstetrics. 2009;280(4):529–38.\nFuldeore MJ, Soliman AMJG, Investigation O. 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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Bmj. 2009;339:b2700.\nFunding\nThis work was supported by the National Natural Science Foundation of China (No. 81772780).\nAuthor information\nAuthors and Affiliations\nContributions\nConceptualization, Ling Zhou; methodology, Ling Zhou; software, Ling Zhou; validation, Ling Zhou and Yan Cheng; formal analysis, Ling Zhou; investigation, Ling Zhou and Yan Cheng; resources, Ling Zhou and Jianhua Gao; data curation, Ling Zhou and Yan Chen; writing—original draft preparation, Ling Zhou; writing—review and editing, Ling Zhou and Shankar Sandhya; supervision, Jianhua Gao; project administration, Guangmei Zhang.\nCorresponding author\nEthics declarations\nConflict of Interest\nThe authors declare that they have no conflict of interest.\nElectronic Supplementary Material\nESM 1 (download PDF )\n(PDF 33 kb)\nRights and permissions\nAbout this article\nCite this article\nZhou, L., Chen, Y., Gao, J. et al. Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis. Reprod. Sci. 27, 793–805 (2020). https://doi.org/10.1007/s43032-019-00024-5\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s43032-019-00024-5","source_license":"public-domain-us","license_restricted":false}