{"paper_id":"a364535a-20a5-432c-accb-07a2644adaf1","body_text":"Abstract\nBackground\nGiant and multilobular endocervical polyps are rare and need to be differentiated from cervical neoplastic lesions.\nCase report\nThe authors report a 29-year-old sexually inactive woman presenting with a prolapsed giant endocervical polyp, associated with malodorous discharge and menorrhagia. The wide-based polyp originated in part from the posterior lip of the exocervix and in part from the endocervix. This trilobular pedunculated mass (90 × 50 × 35 mm) had small cysts on the surface and focal areas of haemorrhage. Microscopic examination revealed areas with classic endocervical mucosal polyp histology intimately mixed with expanses of endometrial stroma and occasional endometrial glands. Immunohistochemically the endometrial stroma showed strong CD10 positivity, glands were oestrogen and progesterone receptor positive and Ki-67 proliferation index was low.\nConclusion\nPolypoid endometriosis of the cervix is a distinct form of endometriosis that may be mistaken for a neoplasm. Five earlier reports of this entity have not described a prolapsed polyp assuming gigantic proportions. We conclude that this condition be considered in the differential diagnosis of polypoid lesions of the cervix.\nReferences\nWright TC, Ronnett BM, Ferenczy A (2011) Benign Diseases of the Cervix. In: Kurman RJ, Ellenson LH, Ronnett BM (eds) Blaustein’s Pathology of the Female Genital Tract, 6th edn. Springer Science, New York, pp 155–191\nBucella D, Frederic B, Noel JC (2008) Giant cervical polyp: a case report and review of a rare entity. Arch Gynecol Obstet 278:295–298\nKhalil AM, Azar GB, Kaspar HG, Abu-Musa AA, Chararah IR, Seoud MA (1996) Giant cervical polyp. A case report. J Reprod Med 41(8):619–621\nAmesse LS, Taneja A, Broxson E, Pfaff-Amesse J (2002) Protruding giant cervical polyp in a young adolescent with a previous rhabdomyosarcoma. J Pediatr Adolesc Gynecol 15:271–277\nMassinde AN, Mpogoro F, Rumanyika RN, Magoma M (2012) Uterine prolapse complicated with a giant cervical polyp. J Low Genit Tract Dis 16(1):64–65\nYi KW, Song SH, Kim KA, Jung WY, Lee JK, Hur JY (2009) Giant endocervical polyp mimicking cervical malignancy: primary excision and hysteroscopic resection. J Minim Invasive Gynecol 16(14):498–500\nAli V, Huang JC, Al-Ibraheemi A, Liu J (2011) Recurrent prolapsed giant uterine polyp comprised of adenomyotic cysts. Int J Clin Med 2(4):478–480\nWang S, Li XC, Lang JH (2011) Cervical endometriosis: clinical character and management experience in a 27-year span. Am J Obstet Gynecol 205(5):452.e1–452.e5\nVeiga-Ferreira MM, Leiman G, Dunbar F, Margolius KA (1987) Cervical endometriosis: facilitated diagnosis by fine needle aspiration cytologic testing. Am J Obstet Gynecol 4(pt1):849–856\nSumathi VP, Mc Cluggage WG (2002) CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol 55(5):391–392\nOthman NH, Othman MS, Ismail AN, Mohammad NZN, Ismail Z (1996) Multiple polypoid endometriosis–a rare complication following withdrawal of gonadotropin releasing hormone (GnRH) agonist for severe endometriosis: a case report. Aust N Z J Obstet Gynaecol 36(2):216–218\nFukunaga M (2001) Uterus-like mass in the uterine cervix: superficial cervical endometriosis with florid smooth muscle metaplasia? Virchows Arch 430(3):302–305\nKano H, Kanda H (2003) Cervical endometriosis presented as a polypoid mass of portio cervix uteri. J Obstet Gynaecol 23(1):84–85\nFelix A, Nogales FF, Arias-Stella J (2010) Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. Int J Gynecol Pathol 29(2):185–188\nKwek JW, H’ng MW, Chew SH, Tay EH (2010) Florid polypoid endometriosis of the cervix with left ureteric obstruction: a mimic of cervical malignancy. Ultrasound Obstet Gynecol 36(2):252–254\nParker RL, Dadmanesh F, Young RH, Clement PB (2004) Polypoid endometriosis: a clinicopathologic analysis of 24 cases and a review of the literature. Am J Surg Pathol 28:285–297\nPark HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS (2009) Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci 24(4):767–771\nConflict of interest\nWe declare that we have no conflict of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nJaiman, S., Gundabattula, S.R., Pochiraju, M. et al. Polypoid endometriosis of the cervix: a case report and review of the literature. Arch Gynecol Obstet 289, 915–920 (2014). https://doi.org/10.1007/s00404-013-3112-5\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-013-3112-5","source_license":"CC0","license_restricted":false}