{"paper_id":"a293e47b-b9b5-4e35-87de-54dd732d1b96","body_text":"19 December 2018 : Laboratory Research\nExpression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics\nMengmeng Zhang1ACE, Chutong Ren1BE, Yinan Xiao1AF, Xiaomeng Xia1DG, Xiaoling Fang1G*DOI: 10.12659/MSM.913885\nMed Sci Monit 2018; 24: BCH9240-9250\nAbstract\nBACKGROUND: Endometriosis is a common gynecologic disorder with enigmatic etiopathogenesis and is characterized by tumor-like biological behaviors. Recently, circular RNAs (circRNAs) have attracted considerable attention because they exert very important functions in the progression of human cancers. However, little is known about the functions and molecular mechanism of circRNAs in endometriosis.\nMATERIAL AND METHODS: A total of 20 patients with ovarian endometriosis and 4 normal endometrium from women free of endometriosis were included in this study. Ectopic endometrium tissues and paired eutopic endometrium tissues were collected from ovarian endometriosis patients. We assessed the expression profiles of circRNAs in endometriosis by microarray analysis. Expression of selected circRNAs in those tissues was detected by quantitative real-time PCR (qRT-PCR). Based on the target prediction, we constructed a circRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network and elucidated circRNAs through Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses.\nRESULTS: We detected 2237 circRNAs, differentially expressed among 3 groups, and then found 8 circRNAs that may be involved in the epithelial-mesenchymal transition process. The qRT-PCR validation suggested that circ_103470 and circ_101102 matched the microarray results. The functional analysis revealed 17 pathways, such as the mTOR signaling pathway, the Hippo signaling pathway, and the HIF-1 signaling pathway, which may be associated with the pathogenesis and development of endometriosis.\nCONCLUSIONS: In general, our results suggest that 2 downregulated circRNAs (circ_103470 and circ_101102) may regulated epithelial-mesenchymal transition in endometriosis via miR-141-5p, which may be a promising therapeutic target in the future.\nKeywords: Endometriosis\nEditorial\n01 January 2026 : Editorial\nEditorial: Increasing Awareness of Lung Cancer in Non-Smokers and Never-Smokers Challenges Current Approaches to Prevention and ScreeningDOI: 10.12659/MSM.952454\nMed Sci Monit 2026; 32:e952454\nIn Press\nClinical Research\nInstitutional and Regional Variations in Access to Clinical Trials and Next-Generation Sequencing in Turkis...Med Sci Monit In Press; DOI: 10.12659/MSM.951027\nClinical Research\nLow-Intensity Blood Flow-Restricted Multi-Joint Exercise Improves Muscle Function in Patients With Patellof...Med Sci Monit In Press; DOI: 10.12659/MSM.950516\nReview article\nMusculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.951283\nClinical Research\nSensory Processing, Dissociation, and Affective Symptoms in Misophonia: A Cross-Sectional Study of 35 AdultsMed Sci Monit In Press; DOI: 10.12659/MSM.950938\nMost Viewed Current Articles\n17 Jan 2024 : Review article 10,187,196\nVaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799\nMed Sci Monit 2024; 30:e942799\n13 Nov 2021 : Clinical Research 3,708,487\nAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788\nMed Sci Monit 2021; 27:e932788\n14 Dec 2022 : Clinical Research 2,341,643\nPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990\nMed Sci Monit 2022; 28:e937990\n16 May 2023 : Clinical Research 706,524\nElectrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387\nMed Sci Monit 2023; 29:e940387","source_license":"CC0","license_restricted":false}