{"paper_id":"a10955b2-b452-489f-a0e2-789af820eba0","body_text":"Publication: Stem cells: Are they the answer to the puzzling etiology of endometriosis?\nAuthors\nOliveira, Flávia R. ; Dela Cruz, Cynthia ; Del Puerto, Helen L. ; Vilamil, Quésia T.M.F. ; Reis, Fernando M. ; Camargos, Aroldo F.\nitem.page.secondaryauthor\nitem.page.director\nPublisher\nF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología\npublication.page.editor\npublication.page.department\nDOI\nitem.page.type\ninfo:eu-repo/semantics/article\nDescription\nAbstract\nEndometriosis is a chronic bening disease characterizaed by the presence of abnormally located tissue resembling the endometrium with glands and\nstroma. This disease has a high degree of morbidity due\nto chronic pelvic pain and infertility. The disease is\nlikely to be polygenic and multifactorial, but the exact\npathogenic mechanisms are still not entirely clear.\nRecently, adult stem cells have been identified in several\ntissues, including the endometrium. These cells are\nprobably involved in the regenerative ability of the\nendometrial cycle, and also in the pathogenesis of\nproliferative gynaecological diseases, such as\nendometriosis. The identification of stem cells in animal\nand human tissues is very complex and the putative stem\ncells are supposed to be found through several assays\nsuch as clonogenicity, label-retaining cells, “side-\npopulation” cells, undifferentiation markers, and cellular\ndifferentiation. Bone marrow-derived stem cells\ntransplanted into humans and animals have also been\nidentified in eutopic endometrium and endometriotic\nimplants. This review evaluates the available evidence\nregarding stem/progenitor cells in the human\nendometrium and explores the possible involvement of\nthese cells in the etiology of endometriosis.\npublication.page.subject\nCitation\nHistology and histopathology, Vol. 27, nº 1 (2012)\nitem.page.embargo\nIr a Estadísticas\nSin licencia Creative Commons.","source_license":"CC0","license_restricted":false}