{"paper_id":"9af75529-d332-4787-8e1f-942a0222979d","body_text":"Research Articles\nThe Cytoskeletal Proteins α-actinin, Ezrin, and Talin are De-expressed in Endometriosis and Endometrioid Carcinoma Compared With Normal Uterine Epithelium\n- Michael Slater\n- M. Cooper\n- C. R. Murphy\nApplied Immunohistochemistry & Molecular Morphology 15(2):p 170-174, June 2007. | DOI: 10.1097/01.pai.0000194762.78889.26\nIn this retrospective study on banked tissue, we found that α-actinin and talin were completely de-expressed in both endometriosis and endometrioid carcinoma tissue. Some patchy, depolarized labeling for ezrin was noted in the endometrioid carcinoma but not in endometriosis. The loss of these proteins in both endometriosis and endometrioid carcinoma tissue indicates a significant change in the integrity of these tissues compared with normal and the possibility that individual cells may break away from the parent histology due to loss of cell adhesion. It also indicates a similarity between endometrioid cancer and endometriosis with respect to epithelial cell function and adhesion.\nCopyright © 2007 Lippincott Williams & Wilkins, Inc.","source_license":"public-domain-us","license_restricted":false}